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Endocrines, Volume 6, Issue 1

March 2025 - 14 articles

Cover Story: How do early-life stressors shape the development of stress regulation? In recent years, the combination of genetically accessible larval zebrafish and water vortex protocols—with a water vortex representing a purely physical, precisely controlled stressor—has enabled the study of both acute and prolonged stress, providing a reproducible approach for examining early-life stress that aligns with the 3Rs principle. These protocols have helped establish zebrafish larvae as a powerful tool for studying cortisol dynamics at stress onset, glucocorticoid feedback, and early-life stress adaptation—findings that lay the foundation for future research on stress regulation across vertebrate models. View this paper
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Articles (14)

  • Article
  • Open Access
3 Citations
6,842 Views
11 Pages

Effects of the Menstrual Cycle Phase on Cortisol Responses to Maximum Exercise in Women With and Without Premenstrual Syndrome

  • Raul Cosme Ramos Prado,
  • Tamires Nunes Oliveira,
  • Bryan Saunders,
  • Roberta Foster,
  • Zsuzsanna Ilona Katalin de Jármy Di Bella,
  • Marcus W. Kilpatrick,
  • Ricardo Yukio Asano,
  • Anthony C. Hackney and
  • Monica Yuri Takito

Objectives: This study investigated the effects of the menstrual cycle phases on cortisol levels before and after a maximal incremental exercise test in women with and without premenstrual syndrome (PMS). Methods: Nineteen healthy, active and eumenor...

  • Review
  • Open Access
1 Citations
1,774 Views
12 Pages

Link Between Umbilical Cord Blood Adipokines and Early Childhood Health

  • Ava M. Boyle,
  • Olivia J. Holland and
  • Deanne H. Hryciw

Introduction: Early-life neurological and inflammatory disorders significantly affect long-term cognitive, social, and emotional development. The ‘Developmental Origins of Health and Disease’ hypothesis states that an adverse intrauterine...

  • Article
  • Open Access
6,147 Views
11 Pages

Background/Objectives: Dienogest 0.5 mg tablets (DNG0.5) taken twice daily (1 mg/day) are more effective than cyclic low-dose estrogen/progestin/combined oral contraceptive (LEP/COC) in ameliorating dysmenorrhea pain and are recommended for dysmenorr...

  • Review
  • Open Access
2,619 Views
14 Pages

Stress responses enable vertebrates to adapt to environmental challenges while maintaining homeostasis. Zebrafish larvae are a valuable model for studying stress regulation due to their genetic accessibility and rapid development. This review examine...

  • Review
  • Open Access
3 Citations
8,334 Views
29 Pages

Nutrition and Physical Activity in Musculoskeletal Health

  • Ligia J. Dominguez,
  • Nicola Veronese,
  • Lee Smith,
  • Francesco Saverio Ragusa,
  • Giovanna Di Bella,
  • Giuseppe Battaglia,
  • Antonino Bianco and
  • Mario Barbagallo

A balanced diet and regular physical activity are essential for maintaining musculoskeletal health. Key nutrients such as calcium, vitamin D, and protein are especially important for preventing falls and fractures. While the benefits of these nutrien...

  • Article
  • Open Access
2,206 Views
8 Pages

Induction of Mandibular Cortical Bone Defects to Study Bone Regeneration

  • Elizabeth K. Vu,
  • Grant Kim,
  • Mitchell J. Shimak,
  • Ismael Y. Karkache,
  • Jinsha Koroth,
  • Emily Chavez,
  • Samuel Mitchell,
  • Rachel B. Clark,
  • Kim C. Mansky and
  • Elizabeth W. Bradley

Background/Objectives: In contrast to endochondral bone healing, the process of intramembranous bone regeneration is poorly understood. This limits our ability to repair and regenerate the craniofacial skeleton to either correct deformity or optimall...

  • Article
  • Open Access
1,725 Views
9 Pages

Impact of Parathormone (PTH) Levels on the Presence of Cardiovascular Disease in Patients with Primary Aldosteronism and Essential Hypertension

  • Álvaro Fernández-Sánchez,
  • Diego Meneses,
  • Emma Raquel Alegre Bellasai,
  • Jersy Cárdenas-Salas,
  • Amalia Paniagua,
  • Clotilde Vázquez and
  • Jorge Gabriel Ruiz-Sánchez

Background/Objectives: Primary aldosteronism (PA) is associated with a higher cardiovascular disease (CVD) risk than essential hypertension (EH) and is mainly driven by the excess of aldosterone production. Studies suggest a relationship between aldo...

  • Obituary
  • Open Access
2,150 Views
15 Pages

Alex Vermeulen (1927–2023) was a leading Belgian endocrinologist whose name will forever remain linked to testosterone and androgen metabolism. As a dedicated scientist and clinician, he made seminal contributions to endocrinology throughout hi...

  • Review
  • Open Access
4 Citations
4,739 Views
19 Pages

Lifestyle Behaviors and Gestational Diabetes Mellitus: A Narrative Review

  • Eleftheria Taousani,
  • Konstantinos-Georgios Papaioannou,
  • Gesthimani Mintziori,
  • Maria G. Grammatikopoulou,
  • Angeliki Antonakou,
  • Maria Tzitiridou-Chatzopoulou,
  • Stavroula Veneti and
  • Dimitrios G. Goulis

Gestational diabetes mellitus (GDM) is a prevalent condition impacting approximately 14% of pregnancies globally, posing significant health risks to mother and child. This review explores the role of diet, physical activity (PA), and sedentary behavi...

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Endocrines - ISSN 2673-396X