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Endocrines, Volume 6, Issue 1

2025 March - 14 articles

Cover Story: How do early-life stressors shape the development of stress regulation? In recent years, the combination of genetically accessible larval zebrafish and water vortex protocols—with a water vortex representing a purely physical, precisely controlled stressor—has enabled the study of both acute and prolonged stress, providing a reproducible approach for examining early-life stress that aligns with the 3Rs principle. These protocols have helped establish zebrafish larvae as a powerful tool for studying cortisol dynamics at stress onset, glucocorticoid feedback, and early-life stress adaptation—findings that lay the foundation for future research on stress regulation across vertebrate models. View this paper
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Articles (14)

  • Article
  • Open Access
3 Citations
9,065 Views
11 Pages

Effects of the Menstrual Cycle Phase on Cortisol Responses to Maximum Exercise in Women With and Without Premenstrual Syndrome

  • Raul Cosme Ramos Prado,
  • Tamires Nunes Oliveira,
  • Bryan Saunders,
  • Roberta Foster,
  • Zsuzsanna Ilona Katalin de Jármy Di Bella,
  • Marcus W. Kilpatrick,
  • Ricardo Yukio Asano,
  • Anthony C. Hackney and
  • Monica Yuri Takito

Objectives: This study investigated the effects of the menstrual cycle phases on cortisol levels before and after a maximal incremental exercise test in women with and without premenstrual syndrome (PMS). Methods: Nineteen healthy, active and eumenor...

(This article belongs to the Section Exercise Endocrinology)
  • Review
  • Open Access
4 Citations
2,768 Views
12 Pages

Link Between Umbilical Cord Blood Adipokines and Early Childhood Health

  • Ava M. Boyle,
  • Olivia J. Holland and
  • Deanne H. Hryciw

Introduction: Early-life neurological and inflammatory disorders significantly affect long-term cognitive, social, and emotional development. The ‘Developmental Origins of Health and Disease’ hypothesis states that an adverse intrauterine...

(This article belongs to the Section Reproductive Endocrinology)
  • Article
  • Open Access
1 Citations
8,614 Views
11 Pages

Background/Objectives: Dienogest 0.5 mg tablets (DNG0.5) taken twice daily (1 mg/day) are more effective than cyclic low-dose estrogen/progestin/combined oral contraceptive (LEP/COC) in ameliorating dysmenorrhea pain and are recommended for dysmenorr...

(This article belongs to the Section Reproductive Endocrinology)
  • Review
  • Open Access
4 Citations
3,901 Views
14 Pages

Stress responses enable vertebrates to adapt to environmental challenges while maintaining homeostasis. Zebrafish larvae are a valuable model for studying stress regulation due to their genetic accessibility and rapid development. This review examine...

  • Review
  • Open Access
10 Citations
13,286 Views
29 Pages

Nutrition and Physical Activity in Musculoskeletal Health

  • Ligia J. Dominguez,
  • Nicola Veronese,
  • Lee Smith,
  • Francesco Saverio Ragusa,
  • Giovanna Di Bella,
  • Giuseppe Battaglia,
  • Antonino Bianco and
  • Mario Barbagallo

A balanced diet and regular physical activity are essential for maintaining musculoskeletal health. Key nutrients such as calcium, vitamin D, and protein are especially important for preventing falls and fractures. While the benefits of these nutrien...

(This article belongs to the Special Issue Feature Papers in Endocrines: 2024)
  • Article
  • Open Access
3,679 Views
8 Pages

Induction of Mandibular Cortical Bone Defects to Study Bone Regeneration

  • Elizabeth K. Vu,
  • Grant Kim,
  • Mitchell J. Shimak,
  • Ismael Y. Karkache,
  • Jinsha Koroth,
  • Emily Chavez,
  • Samuel Mitchell,
  • Rachel B. Clark,
  • Kim C. Mansky and
  • Elizabeth W. Bradley

Background/Objectives: In contrast to endochondral bone healing, the process of intramembranous bone regeneration is poorly understood. This limits our ability to repair and regenerate the craniofacial skeleton to either correct deformity or optimall...

  • Article
  • Open Access
1 Citations
2,813 Views
9 Pages

Impact of Parathormone (PTH) Levels on the Presence of Cardiovascular Disease in Patients with Primary Aldosteronism and Essential Hypertension

  • Álvaro Fernández-Sánchez,
  • Diego Meneses,
  • Emma Raquel Alegre Bellasai,
  • Jersy Cárdenas-Salas,
  • Amalia Paniagua,
  • Clotilde Vázquez and
  • Jorge Gabriel Ruiz-Sánchez

Background/Objectives: Primary aldosteronism (PA) is associated with a higher cardiovascular disease (CVD) risk than essential hypertension (EH) and is mainly driven by the excess of aldosterone production. Studies suggest a relationship between aldo...

(This article belongs to the Section Adrenal Disorders and Electrolyte Balance)
  • Obituary
  • Open Access
3,380 Views
15 Pages

Alex Vermeulen (1927–2023) was a leading Belgian endocrinologist whose name will forever remain linked to testosterone and androgen metabolism. As a dedicated scientist and clinician, he made seminal contributions to endocrinology throughout hi...

  • Review
  • Open Access
5 Citations
6,567 Views
19 Pages

Lifestyle Behaviors and Gestational Diabetes Mellitus: A Narrative Review

  • Eleftheria Taousani,
  • Konstantinos-Georgios Papaioannou,
  • Gesthimani Mintziori,
  • Maria G. Grammatikopoulou,
  • Angeliki Antonakou,
  • Maria Tzitiridou-Chatzopoulou,
  • Stavroula Veneti and
  • Dimitrios G. Goulis

Gestational diabetes mellitus (GDM) is a prevalent condition impacting approximately 14% of pregnancies globally, posing significant health risks to mother and child. This review explores the role of diet, physical activity (PA), and sedentary behavi...

(This article belongs to the Special Issue Advances in Diabetes Care)
  • Review
  • Open Access
5 Citations
6,507 Views
24 Pages

Lipocalin 2 in Obesity and Diabetes: Insights into Its Role in Energy Metabolism

  • Erik Lindstrom,
  • Jessica Deis,
  • David A. Bernlohr and
  • Xiaoli Chen

Background: Lipocalin 2 (LCN2), also known as neutrophil gelatinase-associated lipocalin, is a 25 kDa protein involved in immune defense, inflammation, and metabolism. Results: LCN2 is widely expressed across various tissues, including immune cells,...

(This article belongs to the Section Obesity, Diabetes Mellitus and Metabolic Syndrome)
  • Review
  • Open Access
4 Citations
34,082 Views
19 Pages

Background: Type 2 Diabetes (T2D) is increasingly becoming a critical healthcare priority globally. Medical interventions are primary strategies for managing diabetes, but more recently, diet/nutrition therapy, including the use of functional food pr...

(This article belongs to the Section Obesity, Diabetes Mellitus and Metabolic Syndrome)
  • Case Report
  • Open Access
3,438 Views
7 Pages

Romosozumab as Treatment for Severe Osteoporosis in Heart and Lung Transplant Recipients

  • Lisa M. Raven,
  • Jacqueline R. Center and
  • Christopher A. Muir

Background: Osteoporosis is common in transplant recipients, and fracture risk is high. Standard treatment is with anti-resorptive medications. Despite high fracture rates, there are limited data on the use of anabolic bone therapies in transplant re...

(This article belongs to the Topic Bone as an Endocrine Organ)
  • Article
  • Open Access
4,259 Views
9 Pages

Objective: The effect of testosterone on the development of cardiovascular disease (CVD) is of interest due to the higher risk of CVD in men. This study aims to examine the impact of testosterone depletion and supplementation on atherosclerosis progr...

(This article belongs to the Section Lipid Metabolism and Cardiovascular Endocrinology)
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Endocrines - ISSN 2673-396X