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Transplantology, Volume 6, Issue 1

March 2025 - 7 articles

Cover Story: Pneumocystis jirovecii pneumonia had been a relatively obscure infection in the published literature until a drastic increase in its prevalence in the 1980s and 1990s, causing significant morbidity and mortality.  Sulfamethoxazole–trimethoprim prophylaxis has greatly reduced the incidence of this deadly fungal infection. Traditional prophylactic dosing includes single-strength (400–80 mg) daily or double-strength (800–160 mg) thrice weekly, but is limited by side effects. This study evaluates the efficacy and tolerability of a reduced sulfamethoxazole–trimethoprim single-strength thrice-weekly prophylactic dosing strategy specifically in patients with heart transplants. View this paper
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Articles (7)

  • Article
  • Open Access
1,008 Views
8 Pages

A Single-Center Experience of En Bloc vs. Single Renal Transplantation on Adult Recipients

  • Yoon-Jung Chang,
  • Samuel Simpson,
  • Megan Charette and
  • Obi Ekwenna

Background/Objectives: While there are several debates on en bloc renal transplants and pediatric donors regarding the efficacy and concern for renal mass, multiple studies have supported the notion that transplanting pediatric en bloc kidneys produc...

  • Article
  • Open Access
1,985 Views
16 Pages

Does Eplet Load and Electrostatic Mismatch Score Matter in Kidney Transplantation? A Machine Learning Approach

  • Desmond D. Offei,
  • Dulat Bekbolsynov,
  • Stanislaw Stepkowski and
  • Robert C. Green

Background/Objectives: Kidney transplantation (KT) is the preferred treatment for end-stage renal disease (ESRD), offering improved quality of life, superior survival rates and lower economic burden. However, improving long-term kidney allograft surv...

  • Article
  • Open Access
1,188 Views
10 Pages

Non-Inferiority of Dual Kidney Transplantation: A Retrospective Matched Study

  • Vasco Quaresma,
  • Margarida Carneiro,
  • Lorenzo Marconi,
  • Edgar Tavares da Silva,
  • Roberto Jarimba,
  • Miguel Eliseu,
  • Pedro Nunes and
  • Arnaldo Figueiredo

Background/Objectives: Dual kidney transplantation is a potential technique to reduce the number of discarded kidneys from expanded-criteria donors. Due to allegedly poor outcomes, some centres have abandoned this technique. We aimed to compare dual...

  • Article
  • Open Access
909 Views
10 Pages

Background: This study evaluated the outcomes of sutureless small incision Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK-SI) for treating corneal endothelial decompensation. Methods and Analysis: This retrospective study review...

  • Article
  • Open Access
2 Citations
2,830 Views
9 Pages

Background/Objectives: Pneumocystis jirovecii pneumonia is a significant contributor to morbidity and mortality in patients with solid organ transplants. Sulfamethoxazole–trimethoprim prophylaxis has greatly reduced the incidence of this deadly...

  • Article
  • Open Access
2,687 Views
11 Pages

A Network Meta-Analysis on the Impact of Sirolimus vs. Everolimus on Malignancies After Kidney Transplantation

  • Sebastian Wolf,
  • Stefan Schiele,
  • Matthias Schrempf,
  • Florian Sommer,
  • Mingming Li,
  • Ulrich Wirth,
  • Jens Werner and
  • Joachim Andrassy

Background: mTOR-Is positively influence the occurrence and course of certain tumors after solid organ transplantation. mTOR-inhibitor (mTOR-I) treatment, either alone or in combination with Calcineurininhibitors (CNIs), significantly reduces the inc...

  • Review
  • Open Access
2 Citations
2,855 Views
19 Pages

Solid organ transplantation entails numerous complex medical and ethical decisions. Shared decision-making (SDM) has been advocated as the optimal model for navigating these decisions, providing a collaborative framework that enhances person-centered...

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Transplantology - ISSN 2673-3943