Mitochondrial Reprogramming—What Is the Benefit of Hypothermic Oxygenated Perfusion in Liver Transplantation?
, Philipp Dutkowski 3, Paolo Muiesan 1 and Andrea Schlegel 1,3,*Round 1
Reviewer 1 Report
This is a comprehensive and well-written review on the protective mechanisms, current clinical applications, and future directions of HOPE. The authors are highly experienced in this field, and all self-citations are appropriare. I have no particular issues. Compliments to the authors.
Author Response
Reviewer one:
This is a comprehensive and well-written review on the protective mechanisms, current clinical applications, and future directions of HOPE. The authors are highly experienced in this field, and all self-citations are appropriare. I have no particular issues. Compliments to the authors.
Our reply:
We thank the reviewer for the kind evaluation and the comments regarding our manuscript.
Reviewer 2 Report
The present review focus on the benefit of HOPE for liver transplantation. It was well written, and it includes the principal issues related to this topic.
I would suggest adding a section concerning the ongoing randomized clinical studies even not still published and to control the references.
Author Response
Reviewer two:
The present review focus on the benefit of HOPE for liver transplantation. It was well written, and it includes the principal issues related to this topic.
I would suggest adding a section concerning the ongoing randomized clinical studies even not still published and to control the references.
Our reply:
We thank the reviewer for the evaluation of our manuscript and the suggestion We have added a short section and a Table (2) with ongoing RCTs, currently listed under trial.gov. Please see page 8-9 of the revised manuscript. The references were also checked.
Reviewer 3 Report
This is well-organized review article regarding hypothermic oxygenated perfusion in deceased donor liver transplantation.
It will be of help for readers that authors make a table summarizing upcoming RCTs regarding HOPE procedure.
Author Response
Reviewer three:
This is well-organized review article regarding hypothermic oxygenated perfusion in deceased donor liver transplantation.
It will be of help for readers that authors make a table summarizing upcoming RCTs regarding HOPE procedure.
Our reply:
We thank the reviewer for the kind suggestion and have added Table 2 to summarise the awaited RCTs, expected to finish recruitment or to be published. We have also added a few sentences. Please refer to page 8-9 of the revised manuscript.
