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Article

Combined Effects of Human Chorionic Gonadotropin and Intravaginal Progesterone Device Treatment in the Early Luteal Phase After Artificial Insemination on Conception Rate in Lactating Dairy Cows

by
Ryotaro Miura
1,
Taiki Izumi
2,
Yuriko Wada
1,
Yujiro Hagita
1,
Kosuke Iga
3,
Natsumi Sobu
2,
Akiya Hirase
2,
Osamu Yoneyama
4,
Yo-ichi Miyake
5,
Tsuyoshi Tajima
1,
Tadaharu Ajito
1,
Shingo Haneda
5 and
Motozumi Matsui
5,*
1
Department of Veterinary Medicine, Nippon Veterinary and Life Science University, Kyonan, Musashino 180-8602, Japan
2
Tokachi NOSAI, Kawanishi, Obihiro 089-1182, Japan
3
Division of Advanced Feeding Technology Research, Institute of Livestock and Grassland Science, NARO, Tsukuba 305-0901, Japan
4
Toyonishi Livestock Clinic, Toyonishi, Obihiro 089-1183, Japan
5
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro 080-8555, Japan
*
Author to whom correspondence should be addressed.
Dairy 2025, 6(3), 26; https://doi.org/10.3390/dairy6030026
Submission received: 26 April 2025 / Revised: 26 May 2025 / Accepted: 26 May 2025 / Published: 30 May 2025
(This article belongs to the Section Reproduction)
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Abstract

The combined effects of human chorionic gonadotropin (hCG) treatment on Day 5 (Day 0 = the day of artificial insemination: AI) and intravaginal progesterone device (IVPD) treatment from Day 5 to 19 on the conception rate and plasma sex steroid hormone were examined in lactating dairy cows. In Experiment 1, cows were divided into a non-treatment group (n = 181), untreated; an IVPD group (n = 74), with an IVPD inserted into the vagina from Day 5 to 19; and an hCG + IVPD group (n = 87), with 3000 IU hCG administered intramuscularly on Day 5 and an IVPD inserted into the vagina from Day 5 to 19. The conception rates of the hCG + IVPD group, which underwent ≤3 AIs (52.8%) and >3 AIs (73.3%), and the IVPD group, which underwent >3 AIs (63.0%), were significantly higher than that of the non-treatment group, which underwent ≤3 AIs (34.2%). In Experiment 2, blood samples were collected from the non-treatment group (n = 6), the IVPD group (n = 6), and the hCG + IVPD group (n = 7) on days 5, 8, 12, and 15 from estrus to measure plasma progesterone (P4) and total estrogen (E) concentrations. The plasma P4 concentration of the hCG + IVPD group tended to be higher than that of the non-treatment group on Day 15; however, plasma E concentrations were not different among groups. These results suggest that the conception rate was improved by hCG + IVPD treatment regardless of AI number because of higher plasma P4 concentrations later in the estrous cycle.
Keywords: hCG; intravaginal progesterone device; conception rate hCG; intravaginal progesterone device; conception rate

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MDPI and ACS Style

Miura, R.; Izumi, T.; Wada, Y.; Hagita, Y.; Iga, K.; Sobu, N.; Hirase, A.; Yoneyama, O.; Miyake, Y.-i.; Tajima, T.; et al. Combined Effects of Human Chorionic Gonadotropin and Intravaginal Progesterone Device Treatment in the Early Luteal Phase After Artificial Insemination on Conception Rate in Lactating Dairy Cows. Dairy 2025, 6, 26. https://doi.org/10.3390/dairy6030026

AMA Style

Miura R, Izumi T, Wada Y, Hagita Y, Iga K, Sobu N, Hirase A, Yoneyama O, Miyake Y-i, Tajima T, et al. Combined Effects of Human Chorionic Gonadotropin and Intravaginal Progesterone Device Treatment in the Early Luteal Phase After Artificial Insemination on Conception Rate in Lactating Dairy Cows. Dairy. 2025; 6(3):26. https://doi.org/10.3390/dairy6030026

Chicago/Turabian Style

Miura, Ryotaro, Taiki Izumi, Yuriko Wada, Yujiro Hagita, Kosuke Iga, Natsumi Sobu, Akiya Hirase, Osamu Yoneyama, Yo-ichi Miyake, Tsuyoshi Tajima, and et al. 2025. "Combined Effects of Human Chorionic Gonadotropin and Intravaginal Progesterone Device Treatment in the Early Luteal Phase After Artificial Insemination on Conception Rate in Lactating Dairy Cows" Dairy 6, no. 3: 26. https://doi.org/10.3390/dairy6030026

APA Style

Miura, R., Izumi, T., Wada, Y., Hagita, Y., Iga, K., Sobu, N., Hirase, A., Yoneyama, O., Miyake, Y.-i., Tajima, T., Ajito, T., Haneda, S., & Matsui, M. (2025). Combined Effects of Human Chorionic Gonadotropin and Intravaginal Progesterone Device Treatment in the Early Luteal Phase After Artificial Insemination on Conception Rate in Lactating Dairy Cows. Dairy, 6(3), 26. https://doi.org/10.3390/dairy6030026

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