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A Family of Externally-Functionalised Coordination Cages

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
Author to whom correspondence should be addressed.
Academic Editor: Tanya Ronson
Chemistry 2021, 3(4), 1203-1214;
Received: 20 September 2021 / Revised: 8 October 2021 / Accepted: 11 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Metal-Organic Cages and Their Applications)
New synthetic routes are presented to derivatives of a (known) M8L12 cubic coordination cage in which a range of different substituents are attached at the C4 position of the pyridyl rings at either end of the bis(pyrazolyl-pyridine) bridging ligands. The substituents are (i) –CN groups (new ligand LCN), (ii) –CH2OCH2–CCH (containing a terminal alkyne) groups (new ligand LCC); and (iii) –(CH2OCH2)3CH2OMe (tri-ethyleneglycol monomethyl ether) groups (new ligand LPEG). The resulting functionalised ligands combine with M2+ ions (particularly Co2+, Ni2+, Cd2+) to give isostructural [M8L12]16+ cage cores bearing 24 external functional groups; the cages based on LCN (with M2+ = Cd2+) and LCC (with M2+ = Ni2+) have been crystallographically characterised. The value of these is twofold: (i) exterior nitrile or alkene substituents can provide a basis for further synthetic opportunities via ‘Click’ reactions allowing in principle a diverse range of functionalisation of the cage exterior surface; (ii) the exterior –(CH2OCH2)3CH2OMe groups substantially increase cage solubility in both water and in organic solvents, allowing binding constants of cavity-binding guests to be measured under an increased range of conditions. View Full-Text
Keywords: coordination cage; crystal structure; host-guest chemistry coordination cage; crystal structure; host-guest chemistry
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MDPI and ACS Style

Jackson, G.D.; Tipping, M.B.; Taylor, C.G.P.; Piper, J.R.; Pritchard, C.; Mozaceanu, C.; Ward, M.D. A Family of Externally-Functionalised Coordination Cages. Chemistry 2021, 3, 1203-1214.

AMA Style

Jackson GD, Tipping MB, Taylor CGP, Piper JR, Pritchard C, Mozaceanu C, Ward MD. A Family of Externally-Functionalised Coordination Cages. Chemistry. 2021; 3(4):1203-1214.

Chicago/Turabian Style

Jackson, Garrett D., Max B. Tipping, Christopher G.P. Taylor, Jerico R. Piper, Callum Pritchard, Cristina Mozaceanu, and Michael D. Ward. 2021. "A Family of Externally-Functionalised Coordination Cages" Chemistry 3, no. 4: 1203-1214.

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