Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics
Round 1
Reviewer 1 Report
The work reported in this manuscript is interesting and well presented. However, there should be further improvement and revision before the acceptance. Some comments are:
1. The title should be improved; it should be more precise and represent to the contents.
2. In the abstract; “consolidated by a spark plasma sintering....” add some quantitative data
3. The abstract should be re-written to summarize the work; the abstract should state briefly the purpose of the research, the principal results and major conclusions.
4. The Introduction should be focused and goes over the topic; what is the gab to cover in this work
5. All abbreviations should be defined in the first place only
6. Page 6, Section 2.2...., should be revised with more details and steps are to be clear
7. Discuss in 2.3, the calculations considered gas phase while experiments considered liquid phase
8. Page 5; “This peak is much weaker and wider than the HA” this sentence should be more described and explained
9. Please improve the discussion of the images and XRD. Please add
10. Under results and discussion; Please improve XRD and index please add JCPDS #, idex the peaks in the figure
11. SEM images please deeply discuss the images with respect to porosity and shape see Applied surface science 257 (17), 7746-7751; Desalination and Water Treatment 57 (23), pages 10730-10744;
12. Morphology images please deeply discuss the images with respect to structure
13. Please improve the analysis and interpretation of Adsorption results; please see add Chemical Engineering Journal 378, 122140 (2019); Journal of cleaner production 233, 946-953 (2019); https://doi.org/10.1016/j.trac.2019.115660; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 201, 354-361 ; Journal of Molecular Liquids 253, 297-304 ; Journal of Molecular Liquids 252, 75-82; Sensors and Actuators B: Chemical 254, 1110-1117; Chemical Data Collections 11, 168-182; Chemical Engineering Journal 307, 230-238;
14. Raman spectra of three cellulose products paragraph should be revised with more discussion for better presentation and more informative manner
15. Characterization FTIR. FTIR please improve the discussion and label the bands with the correct functional group:; please add more discussion on EDX mapping and spectroscopy, TEM, etc. please add Journal of Water Supply: Research and Technology—AQUA 64 (8), 892-903; Environmental Science and Pollution Research 22 (21), 16721-16731; https://doi.org/10.1016/j.teac.2020.e00080; Journal of Cleaner Production 172, 2123-2132; Scientific reports 6, 32185; Journal of Colloid and Interface Science 564, 124-133;
16. Can you explain the bands at around 500-600. Label the peaks with bonds
17. please revise and add conditions under the figures captions
18. Please correct the equations
19. Explain why there is band shift in: Raman spectra
20. What about the Method Validation should be discussed.
21. The discussion of Precision: in the results is poor,
22. Introduction; please update introduction with good discussion on tests. Add RSC Advances 6 (79), 75282-75292; Journal of Molecular Liquids 273, 536-542; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 201, 354-361; Chemical Engineering Journal 304, 141-148; Journal of Molecular Structure 1121, 7-15;
23. Captions of the figure and tables must be with complete information, conditions etc
24. The labels of the y and x axis must be corrected
25. The units in the y and x axis must be presented in a correct form
26. Values in the tables should be of uniform significant figures, please recheck
27. Please improve the conclusion with clear quantitative findings
28. More emphasis on finding and its implication may be mentioned in the conclusion section.
29. Highlights should be prepared as per the format
Author Response
Reviewer 1 points and answers:
1. The title should be improved; it should be more precise and represent to the contents.
Revised
2. In the abstract; “consolidated by a spark plasma sintering....” add some quantitative data
Revised
3. The abstract should be re-written to summarize the work; the abstract should state briefly the purpose of the research, the principal results and major conclusions.
Revised
4. The Introduction should be focused and goes over the topic; what is the gab to cover in this work
Revised
5. All abbreviations should be defined in the first place only
Revised
6. Page 6, Section 2.2...., should be revised with more details and steps are to be clear
The objection is incomprehensible
7. Discuss in 2.3, the calculations considered gas phase while experiments considered liquid phase
The objection is incomprehensible
8. Page 5; “This peak is much weaker and wider than the HA” this sentence should be more described and explained
Revised
9. Please improve the discussion of the images and XRD. Please add
Improved
10. Under results and discussion; Please improve XRD and index please add JCPDS #, idex the peaks in the figure
Revised
11. SEM images please deeply discuss the images with respect to porosity and shape see Applied surface science 257 (17), 7746-7751; Desalination and Water Treatment 57 (23), pages 10730-10744;
Revised
12. Morphology images please deeply discuss the images with respect to structure
Sufficiently explained
13. Please improve the analysis and interpretation of Adsorption results; please see add Chemical Engineering Journal 378, 122140 (2019); Journal of cleaner production 233, 946-953 (2019); https://doi.org/10.1016/j.trac.2019.115660; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 201, 354-361 ; Journal of Molecular Liquids 253, 297-304 ; Journal of Molecular Liquids 252, 75-82; Sensors and Actuators B: Chemical 254, 1110-1117; Chemical Data Collections 11, 168-182; Chemical Engineering Journal 307, 230-238;
Revised
14. Raman spectra of three cellulose products paragraph should be revised with more discussion for better presentation and more informative manner
Revised
15. Characterization FTIR. FTIR please improve the discussion and label the bands with the correct functional group:; please add more discussion on EDX mapping and spectroscopy, TEM, etc. please add Journal of Water Supply: Research and Technology—AQUA 64 (8), 892-903; Environmental Science and Pollution Research 22 (21), 16721-16731; https://doi.org/10.1016/j.teac.2020.e00080; Journal of Cleaner Production 172, 2123-2132; Scientific reports 6, 32185; Journal of Colloid and Interface Science 564, 124-133;
Revised
16. Can you explain the bands at around 500-600. Label the peaks with bonds
Revised
17. please revise and add conditions under the figures captions
Revised
18. Please correct the equations
Revised
19. Explain why there is band shift in: Raman spectra
Revised
20. What about the Method Validation should be discussed.
The objection is incomprehensible
21. The discussion of Precision: in the results is poor,
Revised
22. Introduction; please update introduction with good discussion on tests. Add RSC Advances 6 (79), 75282-75292; Journal of Molecular Liquids 273, 536-542; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 201, 354-361; Chemical Engineering Journal 304, 141-148; Journal of Molecular Structure 1121, 7-15;
Due to the structure of the article, it is not possible.
23. Captions of the figure and tables must be with complete information, conditions etc
Revised
24. The labels of the y and x axis must be corrected
The objection is incomprehensible
25. The units in the y and x axis must be presented in a correct form
The objection is incomprehensible
26. Values in the tables should be of uniform significant figures, please recheck
Revised
27. Please improve the conclusion with clear quantitative findings
Revised
28. More emphasis on finding and its implication may be mentioned in the conclusion section.
Revised
29. Highlights should be prepared as per the format
Added
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The article deals with the preparation and analysis of graphene nanoribbons-hydroxyapatite nanocomposite.
Minor comments to the article:
1) AUthors show the Raman spectrum of nanocomposite. It would be interesting to compare it with the HA spectrum.
2) There typing mistakes in Results section (184 line).
3) How the density presented in Fig. 6 was evaluated?
Author Response
Reviewer 2 Points and answers:
1) Authors show the Raman spectrum of nanocomposite. It would be interesting to compare it with the HA spectrum.
Done
2) There typing mistakes in Results section (184 line).
Checked
3) How the density presented in Fig. 6 was evaluated?
The results were statistically evaluated by the Kernel Density Estimation method.
Added to the text along with the references
Author Response File: Author Response.pdf
Reviewer 3 Report
Paper describes a logical series of experiments and careful analytical characterization studies. The figure resolution is quite low and higher resolution would improve the paper. Images of the CNTs before and after the unzipping process would be good to observe as would higher mag fracture surfaces which showed the GNRs and the fracture mode, but is not essential. The supplier of the CNTs and their physical properties could be helpful for readers.
Author Response
Reviewer 3 Points and answers:
Paper describes a logical series of experiments and careful analytical characterization studies. The figure resolution is quite low and higher resolution would improve the paper. Images of the CNTs before and after the unzipping process would be good to observe as would higher mag fracture surfaces which showed the GNRs and the fracture mode, but is not essential. The supplier of the CNTs and their physical properties could be helpful for readers.
High quality images will be submitted separately. CNTs information and GNRs results (before and after unzipping) are similar to the reference was used and corrected in the text.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
The authors have made a large part of the requested changes, therefore the paper is acceptable.
Author Response
Dear Iva Rasic,
Thank you for your kind decision.
The desired corrections were made in the title and text. The changed text has been highlighted.
There is also a change in the authors' section.
Best Regards
