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Gastrointestinal Disorders
Volume 6
Issue 3
10.3390/gidisord6030046
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Article

Metabolic Compartmentalization in Colorectal Cancer Hepatic Metastases and Correlation with Tumor Aggressiveness

by
Nuno Castro
1,
Mariana Fernandes
2,
Ana Pereira
3,
Mariana Costa
3,
Nuno Machado
3,
Cláudio Branco
3,
Carlos Veiga
3,
Adhemar Longatto-Filho
4,5,6,7 and
Sandra F. Martins
4,5,8,*
1
School of Medicine, University of Minho, 4710-057 Braga, Portugal
2
General Surgery at Braga’s Hospital, 4710-243 Braga, Portugal
3
Hepatobiliary Unit, Department of General Surgery at Braga’s Hospital, 4710-243 Braga, Portugal
4
Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal
5
Life and Health Sciences Research Institute (ICVS)/3B’s-PT Government Associate Laboratory, 4806-909 Guimarães, Portugal
6
Molecular Oncology Research Center, Barretos 14784-400, SP, Brazil
7
Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of Sao Paulo, São Paulo 01246-903, SP, Brazil
8
Coloproctology Unit, Department of General Surgery at Braga’s Hospital, 4710-243 Braga, Portugal
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2024, 6(3), 692-705; https://doi.org/10.3390/gidisord6030046
Submission received: 30 May 2024 / Revised: 1 July 2024 / Accepted: 15 July 2024 / Published: 29 July 2024
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Abstract

At the time of colorectal cancer (CRC) diagnosis, approximately 25% of patients present with liver metastases, and 70% develop them during follow-up. This is the primary cause of therapeutic failure and most associated deaths, making it imperative to understand the molecular mechanisms involved in this process and the biological components involved. In the process of anaerobic glycolysis occurring in these cells, to maintain cellular homeostasis, excess lactate is removed via monocarboxylate transporters (MCTs). This study aimed to characterize monocarboxylate transporter 4 (MCT4), human glucose transporter protein isoform 1(GLUT1), cluster of differentiation 147 (CD147), and the acidic cell surface adhesion protein (CD44) in various cellular and histological compartments of liver metastases from CRC in 45 patients diagnosed with metastatic CRC. The characterization revealed significant correlations between the compartmentalization of these markers and the patients’ clinicopathological data. The findings for MCT4, GLUT1, CD147, and CD44 obtained in this study are very promising in relation to considering these markers as therapeutic targets in further investigations.
Keywords: colorectal cancer liver metastases; MCT4; GLUT1; CD44; CD147 colorectal cancer liver metastases; MCT4; GLUT1; CD44; CD147

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MDPI and ACS Style

Castro, N.; Fernandes, M.; Pereira, A.; Costa, M.; Machado, N.; Branco, C.; Veiga, C.; Longatto-Filho, A.; Martins, S.F. Metabolic Compartmentalization in Colorectal Cancer Hepatic Metastases and Correlation with Tumor Aggressiveness. Gastrointest. Disord. 2024, 6, 692-705. https://doi.org/10.3390/gidisord6030046

AMA Style

Castro N, Fernandes M, Pereira A, Costa M, Machado N, Branco C, Veiga C, Longatto-Filho A, Martins SF. Metabolic Compartmentalization in Colorectal Cancer Hepatic Metastases and Correlation with Tumor Aggressiveness. Gastrointestinal Disorders. 2024; 6(3):692-705. https://doi.org/10.3390/gidisord6030046

Chicago/Turabian Style

Castro, Nuno, Mariana Fernandes, Ana Pereira, Mariana Costa, Nuno Machado, Cláudio Branco, Carlos Veiga, Adhemar Longatto-Filho, and Sandra F. Martins. 2024. "Metabolic Compartmentalization in Colorectal Cancer Hepatic Metastases and Correlation with Tumor Aggressiveness" Gastrointestinal Disorders 6, no. 3: 692-705. https://doi.org/10.3390/gidisord6030046

APA Style

Castro, N., Fernandes, M., Pereira, A., Costa, M., Machado, N., Branco, C., Veiga, C., Longatto-Filho, A., & Martins, S. F. (2024). Metabolic Compartmentalization in Colorectal Cancer Hepatic Metastases and Correlation with Tumor Aggressiveness. Gastrointestinal Disorders, 6(3), 692-705. https://doi.org/10.3390/gidisord6030046

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