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Comparison of the Status of Interstitial Cells of Cajal in the Smooth Muscle of the Antrum and Pylorus in Diabetic Male and Female Patients with Severe Gastroparesis
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Per Oral Pyloromyotomy for Gastroparesis: A Systematic Review of the Current Literature and Future Recommendations

1
Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79430, USA
2
Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX 79430, USA
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2020, 2(4), 415-422; https://doi.org/10.3390/gidisord2040038
Received: 8 October 2020 / Accepted: 19 October 2020 / Published: 26 October 2020
(This article belongs to the Special Issue Gastroparesis)
Background: Gastric per oral endoscopic myotomy (GPOEM) was developed as a therapeutic option for gastroparesis after the pylorus was identified as a key target for gastroparesis management. This study includes a systematic literature review of studies in which GPOEM was utilized as therapy for gastroparesis. Methods: A literature search was conducted in three databases (MEDLINE, Scopus and Embase) of articles that included the keywords “GPOEM”, “Gastric per oral endoscopy myotomy” or “per oral pyloromyotomy” and “Gastroparesis” in the abstract or title. The search covered articles published until 29 February 2020. Results: A total of 139 articles were identified. Only 15 articles met the final inclusion criteria and were retrieved for qualitative data synthesis. Conclusion: GPOEM for gastroparesis is shown to have a high success rate among the studies but data interpretations are limited because of small sample sizes and short follow-up. Subjective and objective data prior to and post-GPOEM will be mandatory to establish credibility. The procedure is technically feasible and safe based on the limited studies available. View Full-Text
Keywords: G-POEM; POP; gastric per oral endoscopic myotomy; per oral pyloromyotomy; gastroparesis G-POEM; POP; gastric per oral endoscopic myotomy; per oral pyloromyotomy; gastroparesis
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Chavez, L.O.; Galura, G.; Robles, A.; Bustamante-Bernal, M.A.; McCallum, R. Per Oral Pyloromyotomy for Gastroparesis: A Systematic Review of the Current Literature and Future Recommendations. Gastrointest. Disord. 2020, 2, 415-422.

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