Naringenin Release to Biomembrane Models by Incorporation into Nanoparticles. Experimental Evidence Using Differential Scanning Calorimetry
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. SLN and NLC Preparation
2.3. Speed Vacuum Drying
2.4. Characterization of Nanoparticles
2.5. Stability Tests
2.6. Preparation of MLV
2.7. DSC Analysis
2.7.1. SLN, NLC, and MLV Calorimetric Analysis
2.7.2. Calorimetric Analysis of Dry Samples
2.7.3. Naringenin and MLV Contact Kinetic
2.7.4. SLN/MLV and NLC/MLV Contact Kinetic
3. Results and Discussion
3.1. Nanoparticle Characterization
3.2. DSC Analysis of Nanoparticles
3.3. Calorimetric Analysis of Dry Samples
3.4. Naringenin and MLV Contact Kinetic
3.5. SLN/MLV and NLC/MLV Contact Kinetic
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | Cetil Palmitate (g) | Tegin O (g) | Oleth-20 (g) | Isopropyl Myristate (g) | Naringenin (g) | H2O (g) |
---|---|---|---|---|---|---|
SLN | 1.40 | 0.880 | 1.720 | - | - | 16.000 |
SLN N 1% | 1.40 | 0.880 | 1.720 | - | 0.014 | 15.986 |
SLN N 2% | 1.40 | 0.880 | 1.720 | - | 0.028 | 15.930 |
NLC | 1.22 | 0.772 | 1.520 | 0.500 | - | 15.980 |
NLC N 1% | 1.22 | 0.772 | 1.520 | 0.500 | 0.012 | 15.975 |
NLC N 2% | 1.22 | 0.772 | 1.520 | 0.500 | 0.024 | 15.927 |
Sample | Size ± SD (nm) | P.I. ± SD |
---|---|---|
SLN | 39.62 ± 0.42 | 0.287 ± 0.060 |
SLN N 1% | 31.28 ± 1.32 | 0.350 ± 0.062 |
SLN N 2% | 34.75 ± 0.54 | 0.304 ± 0.046 |
NLC | 31.94 ± 0.82 | 0.304 ± 0.034 |
NLC N 1% | 29.10 ± 0.24 | 0.277 ± 0.054 |
NLC N 2% | 29.93 ± 0.73 | 0.335 ± 0.043 |
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Torrisi, C.; Di Guardia, M.; Castelli, F.; Sarpietro, M.G. Naringenin Release to Biomembrane Models by Incorporation into Nanoparticles. Experimental Evidence Using Differential Scanning Calorimetry. Surfaces 2021, 4, 295-305. https://doi.org/10.3390/surfaces4040025
Torrisi C, Di Guardia M, Castelli F, Sarpietro MG. Naringenin Release to Biomembrane Models by Incorporation into Nanoparticles. Experimental Evidence Using Differential Scanning Calorimetry. Surfaces. 2021; 4(4):295-305. https://doi.org/10.3390/surfaces4040025
Chicago/Turabian StyleTorrisi, Cristina, Marco Di Guardia, Francesco Castelli, and Maria Grazia Sarpietro. 2021. "Naringenin Release to Biomembrane Models by Incorporation into Nanoparticles. Experimental Evidence Using Differential Scanning Calorimetry" Surfaces 4, no. 4: 295-305. https://doi.org/10.3390/surfaces4040025