Next Article in Journal
Surface Functionalisation of Upconversion Nanoparticles with Different Moieties for Biomedical Applications
Previous Article in Journal
The Work Function of TiO2
Article Menu
Issue 1 (December) cover image

Export Article

Open AccessArticle

pH Controlled Impedimetric Sensing of Copper(II) Ion Using Oxytocin as Recognition Element

Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel
Author to whom correspondence should be addressed.
Surfaces 2018, 1(1), 90-95;
Received: 19 August 2018 / Revised: 9 October 2018 / Accepted: 11 October 2018 / Published: 15 October 2018
PDF [1032 KB, uploaded 15 October 2018]


We report the modulation of the specific metal gation properties of a peptide and demonstrate a highly selective sensor for copper(II) ion. The neuropeptide oxytocin (OT) is reported for its high affinity towards Zn2+ and Cu2+ at physiological pH. The binding of the metal ions to OT is tuned by altering the pH of the medium. OT was self-assembled on glassy carbon electrode using surface chemistry, and electrochemical impedance spectroscopy (EIS) was used to probe the binding of Cu2+. Our results clearly indicate that at pH 10.0, the binding of Cu2+ to OT is increased compared to that at pH 7.0, while the binding to Zn2+ becomes almost negligible. This proves that the selectivity of OT towards each of the ions can be regulated simply by controlling the pH of the medium and hence allows the preparation of a sensing device with selectivity to Cu2+. View Full-Text
Keywords: oxytocin; copper(II) ion; impedimetric sensor; surface chemistry oxytocin; copper(II) ion; impedimetric sensor; surface chemistry

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Tadi, K.K.; Alshanski, I.; Hurevich, M.; Yitzchaik, S. pH Controlled Impedimetric Sensing of Copper(II) Ion Using Oxytocin as Recognition Element. Surfaces 2018, 1, 90-95.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Surfaces EISSN 2571-9637 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top