Previous Article in Journal
Non-Surgical Periodontal Defect Fill and Spontaneous Tooth Repositioning: A Case Report
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Reports
Volume 9
Issue 2
10.3390/reports9020187
reports-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Case Report

A Rare Case Reveals Important Consideration of the Diagnosis of Giant Cell Arteritis in Patients with Bilateral Painful Optic Perineuritis

by
Jordan Santos
1,
Faraz Behzadi
1,
S. Mozammil Alam
1,
Thomas C. Varkey
1,*,
David C. Maeng
1,
Ghassan J. Ibrahim
2,
Trent H. Smith
3 and
Alan Wang
1
1
Department of Neurology, University of Arizona College of Medicine, Phoenix, AZ 85004, USA
2
Department of Pathology, University of Arizona College of Medicine, Phoenix, AZ 85004, USA
3
Department of Rheumatology, University of Arizona College of Medicine, Phoenix, AZ 85004, USA
*
Author to whom correspondence should be addressed.
Reports 2026, 9(2), 187; https://doi.org/10.3390/reports9020187 (registering DOI)
Submission received: 30 April 2026 / Revised: 7 June 2026 / Accepted: 10 June 2026 / Published: 15 June 2026
Review Reports Versions Notes

Abstract

Background and Clinical Significance: Giant cell arteritis (GCA) is an autoimmune vasculitis of both medium and large-sized vessels typically affecting females 50 years of age or older. Severe complications can include permanent visual loss, acute coronary syndrome, or stroke. This case will present an atypical presentation of bilateral OPN which can be a rare manifestation of GCA; Case Report: Our patient developed acute, painful worsening central vision loss progressing from right eye to left with bilateral extraocular motility restriction and magnetic resonance image (MRI) revealed bilateral, circumferential optic nerve sheath enhancement suggesting optic perineuritis (OPN). Temporal artery biopsy confirmed GCA with bilateral temporal arteritis. The patient was treated with a high dose course of corticosteroids followed by a taper and was started on upadacitinib with symptomatic improvement; Conclusion: This case underscores OPN as a rarer manifestation of giant cell arteritis that can present with bilateral painful eye movements and vision loss. Early recognition and prompt corticosteroid therapy are essential to prevent irreversible visual impairment.
Keywords: optic perineuritis; giant cell arteritis; acute vision loss; painful extraocular eye movements; case report optic perineuritis; giant cell arteritis; acute vision loss; painful extraocular eye movements; case report

Share and Cite

MDPI and ACS Style

Santos, J.; Behzadi, F.; Alam, S.M.; Varkey, T.C.; Maeng, D.C.; Ibrahim, G.J.; Smith, T.H.; Wang, A. A Rare Case Reveals Important Consideration of the Diagnosis of Giant Cell Arteritis in Patients with Bilateral Painful Optic Perineuritis. Reports 2026, 9, 187. https://doi.org/10.3390/reports9020187

AMA Style

Santos J, Behzadi F, Alam SM, Varkey TC, Maeng DC, Ibrahim GJ, Smith TH, Wang A. A Rare Case Reveals Important Consideration of the Diagnosis of Giant Cell Arteritis in Patients with Bilateral Painful Optic Perineuritis. Reports. 2026; 9(2):187. https://doi.org/10.3390/reports9020187

Chicago/Turabian Style

Santos, Jordan, Faraz Behzadi, S. Mozammil Alam, Thomas C. Varkey, David C. Maeng, Ghassan J. Ibrahim, Trent H. Smith, and Alan Wang. 2026. "A Rare Case Reveals Important Consideration of the Diagnosis of Giant Cell Arteritis in Patients with Bilateral Painful Optic Perineuritis" Reports 9, no. 2: 187. https://doi.org/10.3390/reports9020187

APA Style

Santos, J., Behzadi, F., Alam, S. M., Varkey, T. C., Maeng, D. C., Ibrahim, G. J., Smith, T. H., & Wang, A. (2026). A Rare Case Reveals Important Consideration of the Diagnosis of Giant Cell Arteritis in Patients with Bilateral Painful Optic Perineuritis. Reports, 9(2), 187. https://doi.org/10.3390/reports9020187

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop