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NG2 Glia: Novel Roles beyond Re-/Myelination

Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126 Turin, Italy
Neuroscience Institute of the Cavalieri Ottolenghi Foundation (NICO), Regione Gonzole 10, 10043 Orbassano (Turin), Italy
Author to whom correspondence should be addressed.
Neuroglia 2018, 1(1), 151-175;
Received: 10 June 2018 / Revised: 24 June 2018 / Accepted: 29 June 2018 / Published: 4 July 2018
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Neuron-glia antigen 2-expressing glial cells (NG2 glia) serve as oligodendrocyte progenitors during development and adulthood. However, recent studies have shown that these cells represent not only a transitional stage along the oligodendroglial lineage, but also constitute a specific cell type endowed with typical properties and functions. Namely, NG2 glia (or subsets of NG2 glia) establish physical and functional interactions with neurons and other central nervous system (CNS) cell types, that allow them to constantly monitor the surrounding neuropil. In addition to operating as sensors, NG2 glia have features that are expected for active modulators of neuronal activity, including the expression and release of a battery of neuromodulatory and neuroprotective factors. Consistently, cell ablation strategies targeting NG2 glia demonstrate that, beyond their role in myelination, these cells contribute to CNS homeostasis and development. In this review, we summarize and discuss the advancements achieved over recent years toward the understanding of such functions, and propose novel approaches for further investigations aimed at elucidating the multifaceted roles of NG2 glia. View Full-Text
Keywords: NG2 glia; oligodendrocyte progenitor cells; synapses; neuromodulation; neuroprotection; cell ablation NG2 glia; oligodendrocyte progenitor cells; synapses; neuromodulation; neuroprotection; cell ablation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Parolisi, R.; Boda, E. NG2 Glia: Novel Roles beyond Re-/Myelination. Neuroglia 2018, 1, 151-175.

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