Probe-Based Confocal Laser Endomicroscopy in COVID-19

Igor Vladimirovich Vasilev; Igor Sergeevich Mamenko; Anna Valerievna Makarova; Olga Pavlovna Sokolova; Vladimir Fedorovich Lee; Mahmud Mustafa Mortada; Tatiana Alexandrovna Novickaya; Piotr Kazimirovich Yablonskii

doi:10.5603/ARM.a2021.0067

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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.

Case Report

15 July 2021

Probe-Based Confocal Laser Endomicroscopy in COVID-19

and

Saint-Petersburg State Research Institute of Phthisiopulmonology, Saint-Petersburg, Russia

Saint-Petersburg State University, Medical Faculty, Saint-Petersburg, Russia

Author to whom correspondence should be addressed.

Adv. Respir. Med.2021, 89(4), 456-459;https://doi.org/10.5603/ARM.a2021.0067

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Abstract

Probe-based confocal laser endomicroscopy (pCLE) is a method that produces microscopic imaging of a lung tissue during bronchoscopy. We report a case ot a patient with negative nasopharyngeal swabs and suspected lung cancer who underwent pCLE. The diagnosis of COVID-19 was confirmed by PCR analyses of lavage fluid and transbrohial biopsy. The pCLE image shows density of alveolar thickened fibres, disorganization of elastin network, and multiple large drops of intraalveolar secretions. As far as we know, this is the first pCLE image discribed in patient with COVID-19 at that moment.

Keywords:

confocal laser endomicroscopy; optical biopsy; COVID-19; SARS-CoV-2

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