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Volume 81
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10.5603/ARM.27511
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

Analysis of the Frequency of Isolation and Drug Resistance of Microorganisms Isolated from the Airways of Adult CF Patients Treated in the Institute of Tuberculosis and Lung Disease during 2008–2011

by
Agnieszka Pacholczyk
1,*,
Joanna Nowak
1,
Wojciech Skorupa
2 and
Ewa Augustynowicz-Kopeć
1
1
Department of Microbiology, Institute of Tuberculosis and Lung Diseases, ul. Płocka 26, 01-138 Warsaw, Poland
2
First Department of Lung Diseases, Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2013, 81(2), 105-113; https://doi.org/10.5603/ARM.27511
Submission received: 10 July 2012 / Revised: 18 February 2013 / Accepted: 18 February 2013 / Published: 18 February 2013

Abstract

Introduction: Cystic fibrosis (CF) is the most common genetic autosomal recessive genetic disease. The most serious symptoms are observed in the lungs. Recurrent respiratory infections are the main cause of hospitalization and death among cystic fibrosis patients. Pathogens that commonly infect the airways of adult CF patients include Staphylococcus aureus and Pseudomonas aeruginosa. The aim of this study was to analyse the microorganisms cultured from the airways of adult CF patients and to perform antimicrobial resistance tests of the most frequently isolated bacteria. Material and methods: In this study, 1422 isolates of 89 CF patients were collected during a 4-year period. The microorganisms were cultured and identified according to standard microbiological procedures. Identification and drug susceptibility were performed in a Phoenix (BD) automatic system, Vitek2Compact (bioMérieux) and disk-diffusion method by Kirby-Bauer. Among the 1422 strains, the most frequent pathogens were Pseudomonas aeruginosa (55.6%) and Staphylococcus aureus (37.8%). A total of 482 (61%) strains of 790 isolates of P. aeruginosa were identified as P. aeruginosa of mucoid phenotype. The isolates with mucoid phenotypes were more susceptible than non-mucoid. Eighty-six strains of S. aureus showed resistance to methicillin (MRSA), which accounted for 16.0% of all strains of S. aureus. Conclusions: The analysis of microbiological materials from adult CF patients treated in IGiChP allowed us to determine the prevalence of potentially pathogenic microorganisms. The data obtained are consistent with literature.
Keywords: antimicrobial resistance; cystic fibrosis; Pseudomonas aeruginosa; Staphylococcus aureus antimicrobial resistance; cystic fibrosis; Pseudomonas aeruginosa; Staphylococcus aureus

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MDPI and ACS Style

Pacholczyk, A.; Nowak, J.; Skorupa, W.; Augustynowicz-Kopeć, E. Analysis of the Frequency of Isolation and Drug Resistance of Microorganisms Isolated from the Airways of Adult CF Patients Treated in the Institute of Tuberculosis and Lung Disease during 2008–2011. Adv. Respir. Med. 2013, 81, 105-113. https://doi.org/10.5603/ARM.27511

AMA Style

Pacholczyk A, Nowak J, Skorupa W, Augustynowicz-Kopeć E. Analysis of the Frequency of Isolation and Drug Resistance of Microorganisms Isolated from the Airways of Adult CF Patients Treated in the Institute of Tuberculosis and Lung Disease during 2008–2011. Advances in Respiratory Medicine. 2013; 81(2):105-113. https://doi.org/10.5603/ARM.27511

Chicago/Turabian Style

Pacholczyk, Agnieszka, Joanna Nowak, Wojciech Skorupa, and Ewa Augustynowicz-Kopeć. 2013. "Analysis of the Frequency of Isolation and Drug Resistance of Microorganisms Isolated from the Airways of Adult CF Patients Treated in the Institute of Tuberculosis and Lung Disease during 2008–2011" Advances in Respiratory Medicine 81, no. 2: 105-113. https://doi.org/10.5603/ARM.27511

APA Style

Pacholczyk, A., Nowak, J., Skorupa, W., & Augustynowicz-Kopeć, E. (2013). Analysis of the Frequency of Isolation and Drug Resistance of Microorganisms Isolated from the Airways of Adult CF Patients Treated in the Institute of Tuberculosis and Lung Disease during 2008–2011. Advances in Respiratory Medicine, 81(2), 105-113. https://doi.org/10.5603/ARM.27511

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