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Volume 75
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10.5603/ARM.28001
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

Transbronchial Needle Aspiration as a Diagnostic Method in Lung Cancer and Non-Malignant Mediastinal Adenopathy

by
Artur Szlubowski
1,*,
Jarosław Kużdżał
2,
Jerzy Soja
1,
Ewa Łączyńska
1,
Jolanta Hauer
2,
Piotr Kopiński
3,
Romana Tomaszewska
4 and
Marcin Zieliński
2
1
Oddział Pulmonologii i Pracownia Bronchoskopii Samodzielnego Publicznego Specjalistycznego Szpitala Chorób Płuc w Zakopanem, ul. Gładkie 1, 34-500 Zakopane, Poland
2
Oddział Torakochirurgii Samodzielnego Publicznego Specjalistycznego Szpitala Chorób Płuc w Zakopanem, 34-500 Zakopane, Poland
3
Katedra i Zakład Genoterapii, Collegium Medicum Uniwersytetu Mikołaja Kopernika w Toruniu, 85-094 Bydgoszcz, Poland
4
Katedra Patomorfologii, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, 31-008 Kraków, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2007, 75(1), 5-12; https://doi.org/10.5603/ARM.28001
Submission received: 31 October 2006 / Revised: 13 April 2007 / Accepted: 13 April 2007 / Published: 13 April 2007

Abstract

Introduction: The aim of the study was to assess the diagnostic yield of transbronchial needle aspiration (TBNA) in mediastinal or hilar adenopathy in: lung cancer, staging of NSCLC, sarcoidosis and other non-malignant diseases. Material and methods: Transbronchial needle aspiration was performed in 347 consecutive patients—402 biopsies in groups of lymph nodes: subcarinal (7)—179, all paratracheal (2R, 2L, 4R, 4L)—168 and hilar (10R, 10L)—55, with no real-time imaging guidance, preceded by computed tomography (CT), using 22-gauge needles. All negative results in NSCLC patients were verified by transcervical extended bilateral mediastinal lymphadenectomy (TEMLA) and the remaining patients underwent mediastinoscopy or thoracotomy. Results: TBNA technique was diagnostic in 67.1% of lung cancer patients and in 59.0% of patients with sarcoidosis. In the group of all lung cancer patients specificity was 100%, sensitivity 88.5%, accuracy 91.8% and negative predictive value 77.9% and in diagnosing of lymph nodes involvement in NSCLC was respectively 100%, 86.6%, 90.7% and 76.6%. The high diagnostic yield was comparable for all mediastinal groups. In 80% of NSCLC patients with false negative results of TBNA there was observed partial involvement of metastatic lymph nodes, confirmed by TEMLA. Conclusions: The diagnostic value of TBNA is very high in diagnostics of lung cancer, NSCLC staging and sarcoidosis but much lower in lymphomas, tuberculosis and other non-malignant diseases.
Keywords: transbronchial needle aspiration; transcervical extended bilateral mediastinal lymphadenectomy; lung cancer; sarcoidosis transbronchial needle aspiration; transcervical extended bilateral mediastinal lymphadenectomy; lung cancer; sarcoidosis

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MDPI and ACS Style

Szlubowski, A.; Kużdżał, J.; Soja, J.; Łączyńska, E.; Hauer, J.; Kopiński, P.; Tomaszewska, R.; Zieliński, M. Transbronchial Needle Aspiration as a Diagnostic Method in Lung Cancer and Non-Malignant Mediastinal Adenopathy. Adv. Respir. Med. 2007, 75, 5-12. https://doi.org/10.5603/ARM.28001

AMA Style

Szlubowski A, Kużdżał J, Soja J, Łączyńska E, Hauer J, Kopiński P, Tomaszewska R, Zieliński M. Transbronchial Needle Aspiration as a Diagnostic Method in Lung Cancer and Non-Malignant Mediastinal Adenopathy. Advances in Respiratory Medicine. 2007; 75(1):5-12. https://doi.org/10.5603/ARM.28001

Chicago/Turabian Style

Szlubowski, Artur, Jarosław Kużdżał, Jerzy Soja, Ewa Łączyńska, Jolanta Hauer, Piotr Kopiński, Romana Tomaszewska, and Marcin Zieliński. 2007. "Transbronchial Needle Aspiration as a Diagnostic Method in Lung Cancer and Non-Malignant Mediastinal Adenopathy" Advances in Respiratory Medicine 75, no. 1: 5-12. https://doi.org/10.5603/ARM.28001

APA Style

Szlubowski, A., Kużdżał, J., Soja, J., Łączyńska, E., Hauer, J., Kopiński, P., Tomaszewska, R., & Zieliński, M. (2007). Transbronchial Needle Aspiration as a Diagnostic Method in Lung Cancer and Non-Malignant Mediastinal Adenopathy. Advances in Respiratory Medicine, 75(1), 5-12. https://doi.org/10.5603/ARM.28001

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