New Catechol Derivatives of Safrole and Their Antiproliferative Activity towards Breast Cancer Cells
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Biological Results
Compound | IC 50 (μM) | ||
---|---|---|---|
MCF-7 | MDA-MB-231 | DHF | |
2 | 55.0 ± 7.11 | 37.5 ± 2.65 | >100 |
3 | 98.4 ± 11.6 | 40.2 ± 6.9 | >100 |
4 | >100 | 54.7 ± 6.6 | >100 |
5 | >100 | 54.3 ± 4.1 | >100 |
6 | 97.8 ± 12.4 | 5.9 ± 0.8 | >100 |
7 | >100 | 41.7 ± 7.4 | >100 |
8 | 78.2 ± 8.9 | 57.3 ± 4.1 | >100 |
9 | >100 | >100 | >100 |
10 | 51.3 ± 2.1 | 33.8 ± 4.9 | >100 |
11 | 63.8 ± 5.5 | 27.1 ± 4.4 | >100 |
safrole | >100 | >100 | >100 |
Daunorubicin | 0.19 ± 0.01 | 0.38 ± 0.06 | 14.3 ± 1.85 |
3. Experimental
3.1. General
3.2. Cell Lines
3.3. In vitro Growth Inhibition Assay
4. Conclusions
Acknowledgements
References and Notes
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Madrid Villegas, A.; Espinoza Catalán, L.; Montenegro Venegas, I.; Villena García, J.; Carrasco Altamirano, H. New Catechol Derivatives of Safrole and Their Antiproliferative Activity towards Breast Cancer Cells. Molecules 2011, 16, 4632-4641. https://doi.org/10.3390/molecules16064632
Madrid Villegas A, Espinoza Catalán L, Montenegro Venegas I, Villena García J, Carrasco Altamirano H. New Catechol Derivatives of Safrole and Their Antiproliferative Activity towards Breast Cancer Cells. Molecules. 2011; 16(6):4632-4641. https://doi.org/10.3390/molecules16064632
Chicago/Turabian StyleMadrid Villegas, Alejandro, Luis Espinoza Catalán, Iván Montenegro Venegas, Joan Villena García, and Héctor Carrasco Altamirano. 2011. "New Catechol Derivatives of Safrole and Their Antiproliferative Activity towards Breast Cancer Cells" Molecules 16, no. 6: 4632-4641. https://doi.org/10.3390/molecules16064632