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Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds

Group of Chemistry of Advanced Materials (GQMAT)—Department of Analytical Chemistry and Physical-Chemistry, Universidade Federal do Ceará, Fortaleza CE 60471-970, Brazil
Center for the Development of Nanoscience and Nanotechnology, CEDENNA, Santiago 9170124, Chile
Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, Santiago 8910060, Chile
Paulo Picanço School of Dentistry, Fortaleza CE 06803-440, Brazil
Laboratory of Polymers and Materials Innovation (LPIM)—Department of Organic and Inorganic Chemistry, Universidade Federal do Ceará—UFC, Fortaleza CE 60451-970, Brazil
Departamento de Física, Universidad de Santiago de Chile, Santiago 9170124, Chile
Federal Institute of Education, Science and Technology of Ceará—Campus Camocim, Camocim CE 62400-000, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Francesco Tornabene
J. Compos. Sci. 2021, 5(2), 37;
Received: 23 December 2020 / Revised: 13 January 2021 / Accepted: 18 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue Feature Papers in Journal of Composites Science in 2021)
Hydroxyapatite (HA) is a bioceramic very similar to the mineral component of bones and teeth. It is well established that osteoblasts grow better onto HA-coated metals than on metals alone. Herein, the preparation of a new system consisting of magnetite (Fe3O4) and HA functionalized with oleic acid and simvastatin (SIMV), and incorporated in chitosan (CHI) scaffolds, was undertaken. HA was synthesized by the hydrothermal method, while Fe3O4 was synthesized by co-precipitation. The polymer matrix was obtained using a 2% CHI solution, and allowed to stir for 2 h. The final material was freeze-dried to produce scaffolds. The magnetic properties remained unchanged after the formation of the composite, as well as after the preparation of the scaffolds, maintaining the superparamagnetism. CHI scaffolds were analyzed by scanning electronic spectroscopy (SEM) and showed a high porosity, with very evident cavities, which provides the functionality of bone growth support during the remineralization process in possible regions affected by bone tissue losses. The synthesized composite showed an average particle size between 15 and 23 nm for particles (HA and Fe3O4). The scaffolds showed considerable porosity, which is important for the performance of various functions of the tissue structure. Moreover, the addition of simvastatin in the system can promote bone formation. View Full-Text
Keywords: hydroxyapatite; magnetite; scaffolds; nanocomposite; simvastatin hydroxyapatite; magnetite; scaffolds; nanocomposite; simvastatin
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MDPI and ACS Style

Chaves, A.V.; Freire, R.M.; Feitosa, V.P.; Ricardo, N.M.P.S.; Denardin, J.C.; Andrade Neto, D.M.; Fechine, P.B.A. Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds. J. Compos. Sci. 2021, 5, 37.

AMA Style

Chaves AV, Freire RM, Feitosa VP, Ricardo NMPS, Denardin JC, Andrade Neto DM, Fechine PBA. Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds. Journal of Composites Science. 2021; 5(2):37.

Chicago/Turabian Style

Chaves, Anderson V., Rafael M. Freire, Victor P. Feitosa, Nágila M.P.S. Ricardo, Juliano C. Denardin, Davino M. Andrade Neto, and Pierre B.A. Fechine 2021. "Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds" Journal of Composites Science 5, no. 2: 37.

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