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Production and Characterization of Porous Polymeric Membranes of PLA/PCL Blends with the Addition of Hydroxyapatite

Polymer and Biopolymer Technology Laboratory (TecPBio), Department of Science and Technology, Federal University of São Paulo (UNIFESP), 330 Talim St, São José dos Campos 12231-280, SP, Brazil
National Institute for Space Research (INPE), 1758 dos Astronautas Avenue, São José dos Campos 12227-010, SP, Brazil
Department of Bioscience, Federal University of São Paulo (UNIFESP),136 Silva Jardim St, Santos 11015-020, SP, Brazil
Author to whom correspondence should be addressed.
J. Compos. Sci. 2019, 3(2), 45;
Received: 21 March 2019 / Revised: 16 April 2019 / Accepted: 25 April 2019 / Published: 1 May 2019
(This article belongs to the Special Issue Nanocomposites for Biomedical Implants and Tissue Engineering)
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Polymer membranes have been widely used in guided tissue regeneration (GTR) and guided bone regeneration (GBR). The literature recognizes that poly (lactic acid) (PLA)/poly (ε-caprolactone) (PCL) blends have better physicochemical properties and that a porous polymer surface facilitates cell adhesion and proliferation. In addition, hydroxyapatite (HAp) incorporated into the polymer matrix promotes osteoinduction properties and osteoconduction to the polymer-ceramic biocomposite. Therefore, polymer membranes of PLA/PCL blend with the addition of HAp could be an alternative to be used in GBR. HAp was obtained by precipitation using the mixture of solutions of tetrahydrate calcium nitrate and monobasic ammonium phosphate salts. The porous membranes of the PLA/PCL (80/20) blend with the addition of HAp were obtained by solvent casting with a controlled humidity method, with the dispersion of HAp in chloroform and subsequent solubilization with the components of the blend. The solution was poured into molds for solvent evaporation under a controlled humidity atmosphere. The membranes showed the formation of pores on their surface, together with dispersed HAp particles. The results showed an increase in the surface porosity and improved bioactivity properties with the addition of HAp. Moreover, in biological studies with cell culture, it was possible to observe that the membranes with HAp have no cytotoxic effect on MC3T3 cells. These results indicate a promising use of the new biomaterial for GBR. View Full-Text
Keywords: porous polymeric membranes; PLA; PCL; hydroxyapatite; GBR porous polymeric membranes; PLA; PCL; hydroxyapatite; GBR

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Moura, N.K.; Siqueira, I.A.W.B.; Machado, J.P.B.; Kido, H.W.; Avanzi, I.R.; Rennó, A.C.M.; Trichês, E.S.; Passador, F.R. Production and Characterization of Porous Polymeric Membranes of PLA/PCL Blends with the Addition of Hydroxyapatite. J. Compos. Sci. 2019, 3, 45.

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