Reconstruction of Conchal Defects after Chemically Assisted Dissection of Squamous Cell Carcinoma

Round 1

Reviewer 1 Report

Dear authors,

I congratulate the authors in conducting this study. The article is well prepared and presented. However, the following should be corrected:

1.      Abstract

a.       The authors need to add a short background on the topic before the objective of the study.

b.      No need to write a lay summary in the abstract.

2.       There are no figures in the manuscript file.

3.       Lines 201-4: need a reference.

4.       There are no limitations to the study.

5.       Conclusion: it is better to be in one paragraph.

6.       Lines 235 and 236: mesna should be written as Mesna.

7.       The majority of the references are old. Therefore, updating the references is highly recommended.

Good luck

Minor editing is required.

Author Response

Dear Reviewer,

thank you very much for your comments that were useful to improve the manuscript.

1. Abstract: (a) I added a short background on the topic before the objective of the study. (b) Lay summary was removed.
2. Figures: Figures were added to the manuscript file
3. Lines 201-4: a reference was added
4. Limitations to the study: added (small numbers of participants)
5. Conclusion: I hope I understood your indications about writing them in one paragraph correctly
6. Lines 235 and 236: Mesna is now written correctly
7. References were updated: n. 29 (2023) and n.34 (2022)

Thank you again

Reviewer 2 Report

I have only two remarks:
The Authors should better specify that CADISS is used to detach healthy tissue themselves in case of cancer (cartilage not involved baby the neoplasm and perichondrium for the opposite side) and not cancer from  healthy tissue.
The sentence about actinic damage from exposure while driving car should bee removed because the is no demonstration.

Author Response

Thank you very much for your remarks.

1. As you kindly advised me, I specified that Mesna separates normal tissues from each other (please, see surgical technique)
2. I removed the sentence about the actinic damage from exposure while driving a car (you are right: there is no demonstration).                          Thank you again

Round 2

Reviewer 1 Report

Dear authors,

Thank you very much for revising the manuscript. However, I didn’t see the limitation to the study which should be at the end of the discussion.

It needs minor editing. 

Reviewer 2 Report

The Authors addressed my suggestions