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Fabrication of Demineralized Bone Matrix/Polycaprolactone Composites Using Large Area Projection Sintering (LAPS)

1
Department of Mechanical Engineering, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA
2
Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA
3
LifeLink Foundation, 9661 Delaney Creek Blvd, Tampa, FL 33619, USA
4
Department of Mechanical Engineering, Brigham Young University, Provo, UT 84602, USA
*
Author to whom correspondence should be addressed.
J. Manuf. Mater. Process. 2019, 3(2), 30; https://doi.org/10.3390/jmmp3020030
Received: 30 January 2019 / Revised: 21 March 2019 / Accepted: 2 April 2019 / Published: 10 April 2019
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Abstract

Cadaveric decellularized bone tissue is utilized as an allograft in many musculoskeletal surgical procedures. Typically, the allograft acts as a scaffold to guide tissue regeneration with superior biocompatibility relative to synthetic scaffolds. Traditionally these scaffolds are machined into the required dimensions and shapes. However, the geometrical simplicity and, in some cases, limited dimensions of the donated tissue restrict the use of allograft scaffolds. This could be overcome by additive manufacturing using granulated bone that is both decellularized and demineralized. In this study, the large area projection sintering (LAPS) method is evaluated as a fabrication method to build porous structures composed of granulated cortical bone bound by polycaprolactone (PCL). This additive manufacturing method utilizes visible light to selectively cure the deposited material layer-by-layer to create 3D geometry. First, the spreading behavior of the composite mixtures is evaluated and the conditions to attain improved powder bed density to fabricate the test specimens are determined. The tensile strength of the LAPS fabricated samples in both dry and hydrated states are determined and compared to the demineralized cancellous bone allograft and the heat treated demineralized-bone/PCL mixture in mold. The results indicated that the projection sintered composites of 45–55 wt %. Demineralized bone matrix (DBM) particulates produced strength comparable to processed and demineralized cancellous bone. View Full-Text
Keywords: additive manufacturing; LAPS; demineralized bone matrix; polycaprolactone; tensile strength additive manufacturing; LAPS; demineralized bone matrix; polycaprolactone; tensile strength
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ziaee, M.; Hershman, R.; Mahmood, A.; Crane, N.B. Fabrication of Demineralized Bone Matrix/Polycaprolactone Composites Using Large Area Projection Sintering (LAPS). J. Manuf. Mater. Process. 2019, 3, 30.

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