Study on the Physical and Chemical Behavior of the Carbamazepine-β–Cyclodextrin Inclusion Complex †
by
Adina Magdalena Musuc
1,*, 
Irina Atkinson
1, 
Cornel Munteanu
1,
Ghaleb Abdalameer Abdalrb
2,
Emma Adriana Ozon
3 and
Vlad Tudor Popa
1 1
Romanian Academy, “IlieMurgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania
2
Department of Applied Mathematics and Biostatistics, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
3
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila”University of Medicine and Pharmacy, 020956 Bucharest, Romania
*
Author to whom correspondence should be addressed.
†
Presented at the 1st International Electronic Conference on Pharmaceutics, 1–15 December 2020;
Available online: https://iecp2020.sciforum.net/.
Proceedings 2021, 78(1), 59; https://doi.org/10.3390/IECP2020-08725
Published: 1 December 2020
(This article belongs to the Proceedings of The 1st International Electronic Conference on Pharmaceutics)
Carbamazepine (CBZ) is a sodium channel blocker that has been recommended for the treatment of epilepsy and trigeminal neuralgia for over 40 years [1–3]. Cyclodextrins are the most suitable candidate for the inclusion of CBZ due to the dimension of the internal cavity, in which the active drug can fit properly. The aim of the current study is to evaluate the ability of β-cyclodextrinto include CBZ. The kneading method of complexation in solid state (1:1 molar ratio) was usedto obtain the inclusion complex. For comparison, a simple physical mixture was prepared. Physical and chemical characterizations of the raw materials, physical mixture and the inclusion complex were performedusing Fourier-transforminfrared spectroscopy, X-ray diffraction, scanning electron microscopy and simultaneous thermal analysis. The results obtained using these analytical techniques proved that carbamazepine forms stable complexes with β-cyclodextrin in a 1:1 molar ratio, and the complexation was almost complete.
Acknowledgments
This contribution was elaborated within the “Green Chemistry” research program of the “Ilie Murgulescu” Institute of Physical Chemistry of the Romanian Academy. Support from the EU (ERDF) and the Romanian Government that allowed for acquisition of the research infrastructure under POS-CCEO 2.2.1 project INFRANANOCHEM—Nr. 19/01.03.2009 is gratefully acknowledged.
References
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MDPI and ACS Style
Musuc, A.M.; Atkinson, I.; Munteanu, C.; Abdalrb, G.A.; Ozon, E.A.; Popa, V.T. Study on the Physical and Chemical Behavior of the Carbamazepine-β–Cyclodextrin Inclusion Complex. Proceedings 2021, 78, 59. https://doi.org/10.3390/IECP2020-08725
AMA Style
Musuc AM, Atkinson I, Munteanu C, Abdalrb GA, Ozon EA, Popa VT. Study on the Physical and Chemical Behavior of the Carbamazepine-β–Cyclodextrin Inclusion Complex. Proceedings. 2021; 78(1):59. https://doi.org/10.3390/IECP2020-08725
Chicago/Turabian StyleMusuc, Adina Magdalena, Irina Atkinson, Cornel Munteanu, Ghaleb Abdalameer Abdalrb, Emma Adriana Ozon, and Vlad Tudor Popa. 2021. "Study on the Physical and Chemical Behavior of the Carbamazepine-β–Cyclodextrin Inclusion Complex" Proceedings 78, no. 1: 59. https://doi.org/10.3390/IECP2020-08725
