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10.3390/IECP2020-08694
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Proceeding Paper

Key Features of Solid Lipid Nanoparticles Prepared with Nanoclay and Spring Water Ingredients with Demonstrated Wound Healing Activity: A Pilot Study †

by
Fátima García-Villén
1,*,
Rita Sánchez-Espejo
2,
Ana Borrego-Sánchez
2,
Pilar Cerezo
1,
Raquel de Melo Barbosa
3 and
César Viseras
1,2
1
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, 18071 s/n Granada, Spain
2
Andalusian Institute of Earth Sciences, CSIC-UGR. Avenida de las Palmeras 4, 18100 Armilla, Granada, Spain
3
Department of Pharmacy, University of Rio Grande do Norte, Natal. Gal Gustavo C Farias street, s/n, Natal 59078-970, Brazil
*
Author to whom correspondence should be addressed.
†
Presented at the 1st International Electronic Conference on Pharmaceutics, 1–15 December 2020; Available online: https://iecp2020.sciforum.net/.
Proceedings 2021, 78(1), 56; https://doi.org/10.3390/IECP2020-08694
Published: 1 December 2020
(This article belongs to the Proceedings of The 1st International Electronic Conference on Pharmaceutics)
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Abstract

Solid Lipid Nanoparticles (SLN) emerged in the late 20th century as versatile nanoparticle drug delivery systems. Since then, SLNs have demonstrated to be very useful for the encapsulation of a great number of actives. In particular, the role of SLN in wound healing is pretty recent, since the major part of scientific literature on this field is concentrated during 2019 and 2020. In this pilot study, we propose the formulation of a semisolid system formed by SLN embedded in an inorganic hydrogel with demonstrated wound healing activity. The hot emulsification method was used to prepare the SLN. Subsequently, the SLN were embedded in a wound healing hydrogel composed of a clay mineral (PS9) and a natural spring water (ALI). Granulometry, pH, rheology, and Transmission Electron Microscopy (TEM) microscopy were used to characterize the formulations. Results showed that the use of natural spring water does not affect the SLN’s particle size, unlike PS9, which increased them. TEM microphotographs revealed that this increase in particle size was due to SLN coalescence in the presence of PS9. The pH of all samples was stable for 3 months. Rheology was significantly influenced by the aqueous medium; better results were obtained with ALI. In conclusion, despite the necessity of some improvements, the proposed SLN formulation would be very versatile for wound healing due to the possibility of load different actives inside the SLN together with the wound healing activity of the PS9/ALI hydrogel.
Keywords: solid lipid nanoparticles; sepiolite; spring water; hot emulsification solid lipid nanoparticles; sepiolite; spring water; hot emulsification

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MDPI and ACS Style

García-Villén, F.; Sánchez-Espejo, R.; Borrego-Sánchez, A.; Cerezo, P.; Barbosa, R.d.M.; Viseras, C. Key Features of Solid Lipid Nanoparticles Prepared with Nanoclay and Spring Water Ingredients with Demonstrated Wound Healing Activity: A Pilot Study. Proceedings 2021, 78, 56. https://doi.org/10.3390/IECP2020-08694

AMA Style

García-Villén F, Sánchez-Espejo R, Borrego-Sánchez A, Cerezo P, Barbosa RdM, Viseras C. Key Features of Solid Lipid Nanoparticles Prepared with Nanoclay and Spring Water Ingredients with Demonstrated Wound Healing Activity: A Pilot Study. Proceedings. 2021; 78(1):56. https://doi.org/10.3390/IECP2020-08694

Chicago/Turabian Style

García-Villén, Fátima, Rita Sánchez-Espejo, Ana Borrego-Sánchez, Pilar Cerezo, Raquel de Melo Barbosa, and César Viseras. 2021. "Key Features of Solid Lipid Nanoparticles Prepared with Nanoclay and Spring Water Ingredients with Demonstrated Wound Healing Activity: A Pilot Study" Proceedings 78, no. 1: 56. https://doi.org/10.3390/IECP2020-08694

APA Style

García-Villén, F., Sánchez-Espejo, R., Borrego-Sánchez, A., Cerezo, P., Barbosa, R. d. M., & Viseras, C. (2021). Key Features of Solid Lipid Nanoparticles Prepared with Nanoclay and Spring Water Ingredients with Demonstrated Wound Healing Activity: A Pilot Study. Proceedings, 78(1), 56. https://doi.org/10.3390/IECP2020-08694

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