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Proceeding Paper

Topical Delivery of Amphotericin B Utilizing Transferosomes for the Treatment of Cutaneous Leishmaniasis †

by
Raquel Fernández-García
1,*,
Larry Sttats
2,
Jessica A. Jesus
3,
María Auxiliadora Dea-Ayuela
4,
Francisco Bolás-Fernández
5,
María Paloma Ballesteros
6,
Marcia Dalastra Laurenti
3,
Luiz F.D. Passero
7,8,
Aikaterini Lalatsa
2 and
Dolores R. Serrano
6
1
Departamento de Farmacia Galénica y Tecnología Alimentaria, Facultad de Farmacia. Universidad Complutense de Madrid, Plaza Ramón y Cajal, s/n, 28040 Madrid, Spain
2
Biomaterials, Bio-engineering and Nanomedicines (BioN) Laboratory, Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Pharmaceutical Sciences, University of Portsmouth. St. Michael’s Building, White Swan Road, Portsmouth PO1 2DT, UK
3
Laboratory of Pathology of Infectious Diseases (LIM-50), Medical School, University of São Paulo, Avenida Dr. Arnaldo, 455, 01246903 Cerqueira César, Brazil
4
Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Carrer Santiago Ramón y Cajal, s/n, 46113 Valencia, Spain
5
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal, s/n., 28040 Madrid, Spain
6
Departamento de Farmacia Galénica y Tecnología Alimentaria/Instituto Universitario de Farmacia Industrial (IUFI), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal, s/n, 28040 Madrid, Spain
7
Institute for Biosciences São Vicente, Praça Infante Dom Enrique, São Paulo State University (UNESP), s/n, 11390-900 São Vicente, Brazil
8
Institute for Advanced Studies of Ocean São Vicente. Av. João Francisco Bernsdorp, 1178, 11350-011 São Vicente, Brazil
*
Author to whom correspondence should be addressed.
†
Presented at the 1st International Electronic Conference on Pharmaceutics, 1–15 December 2020; Available online: https://iecp2020.sciforum.net/.
Proceedings 2021, 78(1), 26; https://doi.org/10.3390/IECP2020-08669
Published: 1 December 2020
(This article belongs to the Proceedings of The 1st International Electronic Conference on Pharmaceutics)
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Abstract

Amphotericin B (AmB) is a high-molecular weight poorly soluble drug with a high efficacy in the treatment of infectious caused by Leishmania spp. parasites, which possesses a very low topical bioavailability. Transferosomes (TFs) are ultradeformable vesicles that consist of drugs lipids, an edge activator, and a low amount of ethanol (<10%). They have been engineered and optimized to enhance the permeation of AmB across the skin and, thus, its antiparasitic activity. Drug loading of the formulation resulted in 0.086%, while a good physicochemical stability for 6 months under desiccated conditions was observed. AmB-TFs illustrated a flux of 4.91 ± 0.41 µg/cm2/h across mouse skin. In vivo studies demonstrated a good permeation of the drug after topical application on healthy mouse skin, which was increased using microneedles at early exposure times, while in vivo efficacy studies demonstrated that the parasite load was decreased in a 98.24 ± 1.54%.
Keywords: amphotericin B; transferosomes; ultradeformable lipid vesicles; leishmaniasis amphotericin B; transferosomes; ultradeformable lipid vesicles; leishmaniasis

Share and Cite

MDPI and ACS Style

Fernández-García, R.; Sttats, L.; Jesus, J.A.; Dea-Ayuela, M.A.; Bolás-Fernández, F.; Ballesteros, M.P.; Laurenti, M.D.; Passero, L.F.D.; Lalatsa, A.; Serrano, D.R. Topical Delivery of Amphotericin B Utilizing Transferosomes for the Treatment of Cutaneous Leishmaniasis. Proceedings 2021, 78, 26. https://doi.org/10.3390/IECP2020-08669

AMA Style

Fernández-García R, Sttats L, Jesus JA, Dea-Ayuela MA, Bolás-Fernández F, Ballesteros MP, Laurenti MD, Passero LFD, Lalatsa A, Serrano DR. Topical Delivery of Amphotericin B Utilizing Transferosomes for the Treatment of Cutaneous Leishmaniasis. Proceedings. 2021; 78(1):26. https://doi.org/10.3390/IECP2020-08669

Chicago/Turabian Style

Fernández-García, Raquel, Larry Sttats, Jessica A. Jesus, María Auxiliadora Dea-Ayuela, Francisco Bolás-Fernández, María Paloma Ballesteros, Marcia Dalastra Laurenti, Luiz F.D. Passero, Aikaterini Lalatsa, and Dolores R. Serrano. 2021. "Topical Delivery of Amphotericin B Utilizing Transferosomes for the Treatment of Cutaneous Leishmaniasis" Proceedings 78, no. 1: 26. https://doi.org/10.3390/IECP2020-08669

APA Style

Fernández-García, R., Sttats, L., Jesus, J. A., Dea-Ayuela, M. A., Bolás-Fernández, F., Ballesteros, M. P., Laurenti, M. D., Passero, L. F. D., Lalatsa, A., & Serrano, D. R. (2021). Topical Delivery of Amphotericin B Utilizing Transferosomes for the Treatment of Cutaneous Leishmaniasis. Proceedings, 78(1), 26. https://doi.org/10.3390/IECP2020-08669

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