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Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses

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Faculty of Biomedical Sciences and Medicine FCBM, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
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Centre of Marine Sciences, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
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Division of Aquaculture, Upgrading and Bioprospection, Portuguese Institute for the Sea and Atmosphere, IPMA, Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal
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Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
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Division of Environmental Oceanography, Portuguese Institute for the Sea and Atmosphere, IPMA, Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal
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Marine and Environmental Sciences Centre (MARE), NOVA University of Lisbon, 2829-516 Caparica, Portugal
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MARE—Marine and Environmental Sciences Centre, Faculty of Science, University of Lisbon, Campo Grande, 1749-016 Lisbon, Portugal
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Algarve Biomedical Center ABC, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
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Centre for Biomedical Sciences CBMR, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
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Author to whom correspondence should be addressed.
Presented at the 1st International Electronic Conference on Nutrients—Nutritional and Microbiota Effects on Chronic Disease, 2–15 November 2020; Available online: https://iecn2020.sciforum.net/.
These authors contributed equally to this work.
Proceedings 2020, 61(1), 13; https://doi.org/10.3390/IECN2020-06994
Published: 30 October 2020
In the present work, we aimed to explore the potential of two groups of marine invertebrates—sea cucumbers (Echinodermata) and ascidians (Chordata)—as sources of anti-inflammatory, anti-oxidant, and osteogenic compounds with potential to be used as pharmaceuticals and nutraceuticals for the treatment and prevention of chronic diseases. 24 extracts (ethanol, water, and ethyl acetate) from 4 species of sea cucumbers and 4 species of tunicates were produced and screened in vitro for their anti-inflammatory and anti-oxidant activities and in vivo for osteogenic activity through an assay using zebrafish larvae. Our results showed that ethanolic extracts presented anti-oxidant and anti-inflammatory activity, which revealed to be stronger in the ascidians. The osteogenic activity, which provides evidence of the bioactive potential of these organisms in preventing chronic disorders causing low bone density, was found to be strong in one species of ascidians and 3 of holothurians. This study demonstrates the high potential of extracts from these marine organisms for using as nutraceuticals in the prevention of chronic bone disorders.
Keywords: chronic diseases; nutraceuticals; natural compounds; sea cucumbers; tunicates; anti-inflammatory; anti-oxidant; osteogenic chronic diseases; nutraceuticals; natural compounds; sea cucumbers; tunicates; anti-inflammatory; anti-oxidant; osteogenic
MDPI and ACS Style

Carletti, A.; Cardoso, C.; Juliao, D.; Arteaga, J.L.; Chainho, P.; Dionísio, M.A.; Sales, S.; Gaudêncio, M.J.; Ferreira, I.; Afonso, C.; Lourenço, H.; Cancela, M.L.; Bandarra, N.M.; Gavaia, P.J. Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses. Proceedings 2020, 61, 13. https://doi.org/10.3390/IECN2020-06994

AMA Style

Carletti A, Cardoso C, Juliao D, Arteaga JL, Chainho P, Dionísio MA, Sales S, Gaudêncio MJ, Ferreira I, Afonso C, Lourenço H, Cancela ML, Bandarra NM, Gavaia PJ. Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses. Proceedings. 2020; 61(1):13. https://doi.org/10.3390/IECN2020-06994

Chicago/Turabian Style

Carletti, Alessio; Cardoso, Carlos; Juliao, Diana; Arteaga, Jorge L.; Chainho, Paula; Dionísio, Maria Ana; Sales, Sabrina; Gaudêncio, Maria J.; Ferreira, Inês; Afonso, Cláudia; Lourenço, Helena; Cancela, M. Leonor; Bandarra, Narcisa M.; Gavaia, Paulo J. 2020. "Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses" Proceedings 61, no. 1: 13. https://doi.org/10.3390/IECN2020-06994

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