Next Article in Journal
Synthesis and Biological Evaluation of Aminobisphosphonates—Analogues of Incadronate
Previous Article in Journal
Searches for Magnetic Monopoles: A Review
Article Menu

Article Versions

Export Article

Open AccessAbstract

In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors

1
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
2
Department of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH 43606, USA
3
Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
*
Author to whom correspondence should be addressed.
Current address: Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, UAE.
§
Current address: Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Giza 12613, Egypt.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 63; https://doi.org/10.3390/proceedings2019022063
Published: 12 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [134 KB, uploaded 12 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially cancer. [...]
Keywords: anticancer agents; epigenetics; HDAC inhibitors anticancer agents; epigenetics; HDAC inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tillekeratne, L.M.V.; Al-Hamashi, A.A.; Dlamini, S.; Taylor, W.; Koranne, R.; Pflum, M.K.; Negmeldin, A.T.; Knoff, J. In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors. Proceedings 2019, 22, 63.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top