In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors†
Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
Department of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH 43606, USA
Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
Author to whom correspondence should be addressed.
Current address: Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, UAE.
Current address: Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Giza 12613, Egypt.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Published: 12 August 2019
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Note: In lieu of an abstract, this is an excerpt from the first page.
Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially cancer. [...]
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Tillekeratne, L.M.V.; Al-Hamashi, A.A.; Dlamini, S.; Taylor, W.; Koranne, R.; Pflum, M.K.; Negmeldin, A.T.; Knoff, J. In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors. Proceedings 2019, 22, 63.
Tillekeratne LMV, Al-Hamashi AA, Dlamini S, Taylor W, Koranne R, Pflum MK, Negmeldin AT, Knoff J. In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors. Proceedings. 2019; 22(1):63.
Tillekeratne, L. M. Viranga; Al-Hamashi, Ayad Ayad; Dlamini, Samkeliso; Taylor, William; Koranne, Radhika; Pflum, Mary Kay; Negmeldin, Ahmed T.; Knoff, Joseph. 2019. "In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors." Proceedings 22, no. 1: 63.
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