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Antiproliferative Effects of a Series of Pyrazolines on Lung Cancer

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey
2
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 2nd International Cell Death Research Congress, İzmir, Turkey, 1–4 of November 2018.
Proceedings 2018, 2(25), 1574; https://doi.org/10.3390/proceedings2251574
Published: 5 December 2018
(This article belongs to the Proceedings of Cell Death 2018)
PDF [401 KB, uploaded 5 December 2018]

Abstract

Lung cancer is one of the most diagnosed cancers worldwide and the development of anticancer agents for the treatment of lung cancer is an important task for researchers. For this purpose, herein pyrazoline-based compounds 118 were investigated for their cytotoxic effects on A549 human lung adenocarcinoma and CCD-19Lu human lung fibroblast cell lines using MTT assay. According to the results, 1-(4-methoxyphenyl)-3-(2-furanyl)-5-(4-methylphenyl)-2-pyrazoline (7) was identified as the most promising anticancer agent due to its selective inhibitory effect on A549 cell line with an IC50 value of 138.63 µg/mL when compared with cyclophosphamide (IC50 = 309.97 µg/mL).
Keywords: lung cancer; antiproliferative activity; pyrazoline lung cancer; antiproliferative activity; pyrazoline
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sever, B.; Altıntop, M.D.; Tilki, E.K.; Dikmen, M.; Özdemir, A. Antiproliferative Effects of a Series of Pyrazolines on Lung Cancer. Proceedings 2018, 2, 1574.

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