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Proceeding Paper

3D-Printed, Pocket-Size Diffusion Cells for Skin Permeation Investigation †

1
Smart Materials, Istituto Italiano di Tecnologia, 16163 Genova, Italy
2
In vivo Pharmacology Facility, Istituto Italiano di Tecnologia, 16163 Genova, Italy
3
D3 PharmaChemistry, Istituto Italiano di Tecnologia, 16163 Genova, Italy
4
Nanophysics, Istituto Italiano di Tecnologia, 16163 Genova, Italy
*
Author to whom correspondence should be addressed.
Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018.
These authors equally contributed to the work.
Proceedings 2018, 2(13), 945; https://doi.org/10.3390/proceedings2130945
Published: 10 December 2018
(This article belongs to the Proceedings of EUROSENSORS 2018)
Here we present a novel, compact 3D-printed diffusion cell as an in vitro tool for skin permeation investigation. As proof-of-concept, a diffusion cell for studying the permeation of a model molecule (FITC-dextran, 4 kDa) through explanted mice skin is fabricated and characterized. Good viability of the tissue up to 24 h incubation in the cell is demonstrated via MTT assays. The real-time diffusion of the molecule by means of fluorescence microscopy allowed the determination of its diffusivity through the skin (~2·10−10 m2/s). Our results open the door for the real-time, high-throughput and cost-effective investigation of skin in any labs.
Keywords: transdermal drug-delivery; molecule diffusivity; bottom-up approach; lab-on-chip transdermal drug-delivery; molecule diffusivity; bottom-up approach; lab-on-chip
MDPI and ACS Style

Suarato, G.; Spanò, R.; Bertorelli, R.; Diaspro, A.; Athanassiou, A.; Surdo, S. 3D-Printed, Pocket-Size Diffusion Cells for Skin Permeation Investigation. Proceedings 2018, 2, 945. https://doi.org/10.3390/proceedings2130945

AMA Style

Suarato G, Spanò R, Bertorelli R, Diaspro A, Athanassiou A, Surdo S. 3D-Printed, Pocket-Size Diffusion Cells for Skin Permeation Investigation. Proceedings. 2018; 2(13):945. https://doi.org/10.3390/proceedings2130945

Chicago/Turabian Style

Suarato, Giulia, Raffaele Spanò, Rosalia Bertorelli, Alberto Diaspro, Athanassia Athanassiou, and Salvatore Surdo. 2018. "3D-Printed, Pocket-Size Diffusion Cells for Skin Permeation Investigation" Proceedings 2, no. 13: 945. https://doi.org/10.3390/proceedings2130945

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