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Abstract

Efficient Development of Microfluidic Solutions for Bioanalytical “Point-of-Use” Testing towards High-Technology-Readiness Levels—A Platform-Based Design-for-Manufacture Approach †

FPC@DCU—Fraunhofer Project Centre for Embedded Bioanalytical Systems, School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland
Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018.
Proceedings 2018, 2(13), 1097; https://doi.org/10.3390/proceedings2131097
Published: 11 February 2019
(This article belongs to the Proceedings of EUROSENSORS 2018)
Integrated microfluidic technologies have demonstrated significant benefits for a range of applications, mostly in the context of decentralised bioanalytical multiparameter testing at the point of use with primary applications in healthcare, pharma, veterinary medicine, agrifood and life-science research as well as monitoring of the environment, infrastructures and industrial processes. For efficient development, FPC@DCU [1], the Fraunhofer Project Centre for Embedded Bioanalytical Systems at Dublin City University—a joint initiative by Science Foundation Ireland (SFI) and Fraunhofer-Gesellschaft, pursues a coherent, design-for-manufacture (DfM) themed platform approach [2]; new, microfluidics-enabled “sample-to-answer” solutions are generated from a common library of geometrically parametrized fluidic elements for flow control, e.g., valves and routers, for coordinating sequential and parallelized liquid handling protocols comprising of mixing, metering, aliquoting, reagent storage and particle removal function. The impact of manufacturing tolerances and artefacts on functionality is considered along all stages of scale-up, ranging from prototyping by ultraprecision milling to tooling, polymer replication (e.g., by injection molding), biofunctionalization and automated assembly of multi-component systems. The DfM paradigm thus assures seamless scale-up from prototyping to pilot series for fluidic design optimization and bioassay development and eventually larger-scale production, thus substantially supporting regulatory approval and significantly de-risking commercial product development. FPC@DCU’s platform-based, DfM-guided strategy to reach high technology-readiness levels (TRLs) is illustrated along the example of FPC@DCU’s centrifugal microfluidic “Lab-on-a-Disc” (LoaD) platform.

References

  1. FPC@DCU—Fraunhofer Project Centre for Embedded Bioanalytical Systems at Dublin City University—A Joint Initiative by Science Foundation Ireland and Fraunhofer-Gesellschaft. Available online: www.dcu.ie/fpc (accessed on 28 May 2018).
  2. Ducrée, J.; Zengerle, R. (Eds.) FlowMap—Microfluidics Roadmap for the Life Sciences; Books on Demand GmbH: Norderstedt, Germany, 2004; ISBN 3833407441. [Google Scholar]
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MDPI and ACS Style

Ducrée, J. Efficient Development of Microfluidic Solutions for Bioanalytical “Point-of-Use” Testing towards High-Technology-Readiness Levels—A Platform-Based Design-for-Manufacture Approach. Proceedings 2018, 2, 1097. https://doi.org/10.3390/proceedings2131097

AMA Style

Ducrée J. Efficient Development of Microfluidic Solutions for Bioanalytical “Point-of-Use” Testing towards High-Technology-Readiness Levels—A Platform-Based Design-for-Manufacture Approach. Proceedings. 2018; 2(13):1097. https://doi.org/10.3390/proceedings2131097

Chicago/Turabian Style

Ducrée, Jens. 2018. "Efficient Development of Microfluidic Solutions for Bioanalytical “Point-of-Use” Testing towards High-Technology-Readiness Levels—A Platform-Based Design-for-Manufacture Approach" Proceedings 2, no. 13: 1097. https://doi.org/10.3390/proceedings2131097

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