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Abstract

Testosterone and Cervicovaginal Health in Transgender Men: An Integrative Review of Clinical Repercussions and the SUS †

by
João V. A. Sabate
*,
Luanna R. Araujo
,
Lara K. P. G. Silva
and
Sussana S. T. Barbosa
Department of Biomedicine, Faculty of Health Sciences, University of the Federal District (UDF), Brasília 71907-650, Brazil
*
Author to whom correspondence should be addressed.
Presented at the 6th International Congress on Health Innovation—INOVATEC 2025, Hybrid, 21–23 November 2025.
Proceedings 2026, 137(1), 28; https://doi.org/10.3390/proceedings2026137028
Published: 25 February 2026
(This article belongs to the Proceedings of The 6th International Congress on Health Innovation—INOVATEC 2025)
Introduction: This study aimed to analyze scientific data on hormonal modulation with testosterone, its effects on cervicovaginal health in transgender men, and the role of the Unified Health System (SUS) in providing care to these individuals. The goal was to understand the physiological and clinical repercussions of hormonal therapy, associated with cytological changes and main pathologies in individuals with preserved gynecological organs. Methodology: An integrative review was carried out using databases such as PubMed, SciELO, and Google Scholar, as well as documents from the Brazilian Ministry of Health. Original articles in Portuguese and English, literature reviews, and official documents addressing testosterone therapy, cervicovaginal health, or transgender health policies were included. The material was selected in two stages: title screening and critical analysis. Results: Testosterone proved essential for gender affirmation, promoting physical changes and psychosocial benefits. However, cervical alterations such as atrophy, microbiota modifications, and limitations in performing cytological exams were observed. Beyond clinical aspects, social barriers, discrimination, and insufficient professional training continue to hinder quality care. In this context, SUS, through the National Policy for Comprehensive LGBT Health and the Transsexualizing Process, plays a key role in reducing inequalities and ensuring access to multidisciplinary follow-up and comprehensive attention. Conclusions: Comprehensive care for the transgender population goes beyond diagnoses and surgeries, constituting a matter of public health and equity. It is necessary to deepen knowledge about the effects of exogenous testosterone on cervicovaginal health, improve sampling and evaluation techniques, and strengthen professional training to ensure dignified and inclusive care.

Author Contributions

Conceptualization, J.V.A.S. and L.R.A.; data curation, J.V.A.S., L.R.A., L.K.P.G.S. and S.S.T.B.; formal analysis, J.V.A.S., L.R.A. and L.K.P.G.S.; investigation, J.V.A.S., L.R.A., L.K.P.G.S. and S.S.T.B.; methodology, S.S.T.B.; project administration, J.V.A.S.; supervision, J.V.A.S.; writing—original draft preparation, J.V.A.S., L.R.A., L.K.P.G.S. and S.S.T.B.; writing—review and editing, L.R.A. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Ethical review and approval were waived for this study because it is an integrative literature review based exclusively on previously published studies and publicly available data.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Conflicts of Interest

The authors declare no conflict of interest.
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Share and Cite

MDPI and ACS Style

Sabate, J.V.A.; Araujo, L.R.; Silva, L.K.P.G.; Barbosa, S.S.T. Testosterone and Cervicovaginal Health in Transgender Men: An Integrative Review of Clinical Repercussions and the SUS. Proceedings 2026, 137, 28. https://doi.org/10.3390/proceedings2026137028

AMA Style

Sabate JVA, Araujo LR, Silva LKPG, Barbosa SST. Testosterone and Cervicovaginal Health in Transgender Men: An Integrative Review of Clinical Repercussions and the SUS. Proceedings. 2026; 137(1):28. https://doi.org/10.3390/proceedings2026137028

Chicago/Turabian Style

Sabate, João V. A., Luanna R. Araujo, Lara K. P. G. Silva, and Sussana S. T. Barbosa. 2026. "Testosterone and Cervicovaginal Health in Transgender Men: An Integrative Review of Clinical Repercussions and the SUS" Proceedings 137, no. 1: 28. https://doi.org/10.3390/proceedings2026137028

APA Style

Sabate, J. V. A., Araujo, L. R., Silva, L. K. P. G., & Barbosa, S. S. T. (2026). Testosterone and Cervicovaginal Health in Transgender Men: An Integrative Review of Clinical Repercussions and the SUS. Proceedings, 137(1), 28. https://doi.org/10.3390/proceedings2026137028

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