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Extended Abstract

Protective Effects of Dietary Polyphenols on Arterial Stiffness †

Natural Products and Food—Research & Analysis (NatuRA), University of Antwerp, 2610 Antwerp, Belgium
Laboratory of Physiopharmacology, University of Antwerp, 2610 Antwerp, Belgium
Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056, Lisboa, Portugal
Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic
Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia
Author to whom correspondence should be addressed.
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg 25–27 March 2019.
Proceedings 2019, 11(1), 40;
Published: 5 August 2019
(This article belongs to the Proceedings of CA16112 - Luxemburg 2019)
Cardiovascular diseases are the major cause of mortality, with 17.9 million deaths/year worldwide and 3.9 million deaths/year in Europe, representing a cost to the EU economy of €210 billion/year [1,2]. Arterial stiffness has been shown to increase cardiovascular morbidity and mortality [3,4]. It is a complex phenomenon characterized by decreased vascular distensibility [5]. This degenerative process is influenced by ageing and several risk factors but is mainly associated with changes in the extracellular components of elastic arteries [5,6]. Several factors, including vascular function, oxidative stress, inflammation, glycation and autophagy contribute to the pathophysiology of arterial stiffness. Considering that the structural degeneration of the extracellular matrix of the vascular wall is practically irreversible with current therapies, it is extremely important to evaluate the impact of preventive interventions, for example reducing the impact of aging on increasing stiffness [5]. Most cardiovascular diseases can be prevented by addressing behavioral risk factors, of which dietary factors make the largest contribution [2]. Polyphenols are a widespread class of plant secondary metabolites that are found in several foods and possess a diverse range of biological activities. Dietary polyphenols display pleiotropic effects, interacting with most mechanisms involved in arterial stiffness etiology. Therefore, they could constitute an interesting option to target vascular stiffening. In vivo activity of polyphenols or polyphenol containing foods is known [7]. For several polyphenols or polyphenol containing foods, including cocoa, grapes, berries and olive, intervention studies point to a beneficial effect on vascular stiffness [8,9,10,11,12]. With regard to olive polyphenols specifically, our previous intervention study has shown blood pressure lowering effects [12,13,14,15]. In order to further elucidate mechanisms of action, we recently focused on specific studies investigating the potency of olive polyphenols as autophagy-inducing compounds, and the contribution of this mechanism to their atheroprotective effects.


This article is based upon work from COST Action NutRedOx-CA16112 supported by COST (European Cooperation in Science and Technology).

Conflicts of Interest

The authors declare no conflict of interest.


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Share and Cite

MDPI and ACS Style

Hermans, N.; Steenput, B.; Roth, L.; Meyer, G.D.; Santos, C.N.d.; Valentová, K.; Dambrova, M.; Bruyne, T.D. Protective Effects of Dietary Polyphenols on Arterial Stiffness. Proceedings 2019, 11, 40.

AMA Style

Hermans N, Steenput B, Roth L, Meyer GD, Santos CNd, Valentová K, Dambrova M, Bruyne TD. Protective Effects of Dietary Polyphenols on Arterial Stiffness. Proceedings. 2019; 11(1):40.

Chicago/Turabian Style

Hermans, Nina, Bieke Steenput, Lynn Roth, Guido De Meyer, Claudia Nunes dos Santos, Kateřina Valentová, Maija Dambrova, and Tess De Bruyne. 2019. "Protective Effects of Dietary Polyphenols on Arterial Stiffness" Proceedings 11, no. 1: 40.

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