Helicobacter pylori is one of the most common human infections worldwide and it is estimated that more than half of global population is affected. This microorganism induces oxidative stress in gastric mucosa and causes chronic gastritis, duodenal peptic ulcer, gastric cancer, and as reasonably suspected a number of extragastric diseases [1,2]. Our research was focused on both local (on the level of gastric mucosa) and systemic effects of H. pylori positivity in patients with duodenal peptic ulcer and healthy volunteers. It was shown that increased accumulation of 4-hydroxynonenal (HNE) persists even despite H. pylori eradication [3,4]. We performed an interventional study to evaluate effects of Amaranth oil on accumulation of HNE-histidine adducts in gastric mucosa of patients undergoing routine anti-H. pylori treatment. It was demonstrated that Amaranth oil supplementation provided significant improvement of gastric mucosa morphological pattern and also had a positive effect on heart rate variability [5]. In a separate study we demonstrated that H. pylori in apparently healthy sedentary young male subjects is associated with higher heart rate, sympathetic activity and insulin resistance, however, we detected no changes in parameters reflecting inflammatory profile, metabolic parameters or oxidative stress [6,7,8]. In summary, there is a growing evidence of systemic metabolic effects of H. pylori infection not only in patients with overt gastrointestinal disorders, but also in apparently asymptomatic healthy subjects. Thus H. pylori status should be seriously considered in human studies focusing on both pharmacological and non-pharmacological approaches.
Author Contributions
Conceptualization, A.C., S.H., M.L. and O.Y.; clinical studies A.C., S.H. and O.Y.; laboratory investigations, S.H.; resources, A.C.; data processing, A.C.; writing—original draft preparation, A.C., M.L.; writing—review and editing, A.C., S.H., M.L. and O.Y.; supervision, A.C., O.Y.; project administration, A.C.; funding acquisition, A.C., S.H.
Funding
This publication is based upon work from COST Action NutRedOx-CA16112, COST Actions B35 “LPO-lipid peroxidation associated disorders”, CM1001 “Chemistry of non-enzymatic protein modification–modulation of protein structure and function” supported by COST (European Cooperation in Science and Technology). A.C. was supported by the Georg Forster (HERMES) Scholarship from Alexander Von Humboldt Foundation (Bonn, Germany).
Acknowledgments
The authors are grateful to all the colleagues and collaborators that contributed to the research that has been done at the Department of Internal Medicine #1 and other departments of Danylo Halytskyi Lviv National Medical University (Lviv, Ukraine), Rudjer Boskovic Institute and School of Medicine of the University of Zagreb (Zagreb, Croatia), Department of Cell Biology and Physiology, University of Salzburg, Salzburg, Austria, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.
Conflicts of Interest
The authors declare no conflict of interest.
References
- Cherkas, A.; Zarkovic, N. 4-hydroxynonenal in redox homeostasis of gastrointestinal mucosa: Implications for the stomach in health and diseases. Antioxidants 2018, 7, 118. [Google Scholar] [CrossRef] [PubMed]
- Yelisyeyeva, O.; Cherkas, A.; Zarkovic, K.; Semen, K.; Kaminskyy, D.; Waeg, G.; Zarkovic, N. The distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients. Free Radic Res. 2008, 42, 205–211. [Google Scholar] [CrossRef] [PubMed]
- Cherkas, A.; Yelisyeyeva, O.; Semen, K.; Zarkovic, K.; Kaminskyy, V.D.; Cipak, A.; Jaganjac, M.; Lutsyk, A.D.; Waeg, G.; Zarkovicet, N. Persistent accumulation of 4-hydroxynonenal-protein adducts in gastric mucosa after Helicobacter pylori eradication. Coll. Antropol. 2009, 33, 815–821. [Google Scholar] [PubMed]
- Semen, K.O.; Yelisyeyeva, O.P.; Kaminskyy, D.V.; Cherkas, A.P.; Zarkovic, K.; Lutsyk, O.; Cipak, A.; Jaganjac, M.; Zarkovic, N. Interval hypoxic training in complex treatment of Helicobacter pylori-associated peptic ulcer disease. Acta Biochim. Pol. 2010, 57, 199–208. [Google Scholar] [CrossRef] [PubMed]
- Cherkas, A.; Zarkovic, K.; Cipak Gasparovic, A; Jaganjac, M.; Milkovic, L.; Abrahamovych, O.; Yatskevych, O.; Waeg, G.; Yelisyeyeva, O.; Zarkovic, N. Amaranth oil reduces accumulation of 4-hydroxynonenal-histidine adducts in gastric mucosa and improves heart rate variability in duodenal peptic ulcer patients undergoing Helicobacter pylori eradication. Free Radic Res. 2018, 52, 135–149. [Google Scholar] [CrossRef] [PubMed]
- Cherkas, A.; Golota, S.; Guéraud, F.; Abrahamovych, O.; Pichler, C.; Nersesyan, A.; Krupak, V.; Bugiichyk, V.; Yatskevych, O.; Pliatsko, M.; et al. A Helicobacter pylori-associated insulin resistance in asymptomatic sedentary young men does not correlate with inflammatory markers and urine levels of 8-iso-PGF2-α or 1,4-dihydroxynonane mercapturic acid. Arch. Physiol. Biochem. 2018, 124, 275–285. [Google Scholar] [CrossRef] [PubMed]
- Cherkas, A.; Eckl, P.; Gueraud, F.; Abrahamovych, O.; Serhiyenko, V.; Yatskevych, O.; Pliatsko, M.; Golota, S. Helicobacter pylori in sedentary men is linked to higher heart rate, sympathetic activity, and insulin resistance but not inflammation or oxidative stress. Croat. Med. J. 2016, 57, 141–149. [Google Scholar] [CrossRef] [PubMed]
- Cherkas, A.; Abrahamovych, O.; Golota, S.; Nersesyan, A.; Pichler, C.; Serhiyenko, V.; Knasmüller, S.; Zarkovic, N.; Eckl, P. The correlations of glycated hemoglobin and carbohydrate metabolism parameters with heart rate variability in apparently healthy sedentary young male subjects. Redox Biol. 2015, 5, 301–7. [Google Scholar] [CrossRef] [PubMed]
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