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Abstract

Antimicrobial Activity of Amino Acid Analogues and Their Derivatives †

by
Dácil Hernández
*,
Carlos Saavedra
,
Carmen Carro
,
Alicia Boto
and
José M. Pérez de Lastra
Instituto de Productos Naturales y Agrobiologia CSIC, Avda. Astrofísico Fco. Sánchez, 3, 38206-La Laguna,Tenerife, Spain
*
Author to whom correspondence should be addressed.
†
Presented at the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain, 8 September 2017.
Proceedings 2017, 1(6), 657; https://doi.org/10.3390/proceedings1060657
Published: 19 October 2017
(This article belongs to the Proceedings of Proceedings of the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain)
Versions Notes
Libraries of compounds containing unnatural amino acids or amino acid analogues were prepared from inexpensive substrates using sustainable processes [1,2,3]. The compounds were evaluated for antimicrobial activity against different pathogens.
Proceedings 01 00657 i001

Author Contributions

D.H. and A.B. supervised the work carried out by D.H., C.S., A.B. and C.C.; J.M.P.d.L. supervised the antimicrobial screenings.

Acknowledgments

This work was supported by the Research Program SAF-2013-48399-R, Plan Estatal de I + D, Ministerio de Economía y Competitividad, Spain, and European Social Funds (FSE). D.H. thanks CSIC (Spanish Research Council) her JAE postdoctoral research contract, and also thanks her current contract financed by Cabildo de Tenerife, Program TF INNOVA 2016-21 (with MEDI & FDCAN Funds). C.S. thanks Gobierno de Canarias for his former research contract, and MINECO for his current Torres Quevedo contract (PTQ-15-07923) with BIOSIGMA SL. C.C. thanks MINECO for her Doctorados Industriales contract (D1406736) with BIOSIGMA SL.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Saavedra, C.J.; Boto, A.; Hernández, R. “Customizable” Units in Di- and Tripeptides: Selective Conversion into Substituted Dehydroamino Acids. Org. Lett. 2012, 14, 3788–3791. [Google Scholar] [CrossRef] [PubMed]
  2. Boto, A.; Hernández, D.; Hernández, R. One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues. Eur. J. Org. Chem. 2010, 6633–6642. [Google Scholar] [CrossRef]
  3. Hernández, D.; Boto, A.; Guzmán, D.; Alvarez, E. Metal-free, direct conversion of α-amino acids into α-keto γ-amino esters for the synthesis of α,γ-peptides. Org. Biomol. Chem. 2017, 15, 7736–7742. [Google Scholar] [CrossRef] [PubMed]
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MDPI and ACS Style

Hernández, D.; Saavedra, C.; Carro, C.; Boto, A.; Lastra, J.M.P.d. Antimicrobial Activity of Amino Acid Analogues and Their Derivatives. Proceedings 2017, 1, 657. https://doi.org/10.3390/proceedings1060657

AMA Style

Hernández D, Saavedra C, Carro C, Boto A, Lastra JMPd. Antimicrobial Activity of Amino Acid Analogues and Their Derivatives. Proceedings. 2017; 1(6):657. https://doi.org/10.3390/proceedings1060657

Chicago/Turabian Style

Hernández, Dácil, Carlos Saavedra, Carmen Carro, Alicia Boto, and José M. Pérez de Lastra. 2017. "Antimicrobial Activity of Amino Acid Analogues and Their Derivatives" Proceedings 1, no. 6: 657. https://doi.org/10.3390/proceedings1060657

APA Style

Hernández, D., Saavedra, C., Carro, C., Boto, A., & Lastra, J. M. P. d. (2017). Antimicrobial Activity of Amino Acid Analogues and Their Derivatives. Proceedings, 1(6), 657. https://doi.org/10.3390/proceedings1060657

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