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Article

Seroprevalence of Strongyloides stercoralis in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain)

by
Cristina Carranza-Rodríguez
1,2,*,†,
Laura López-Delgado
1,2,†,
Álvaro Granados-Magan
2 and
José-Luis Pérez-Arellano
1,2
1
Unidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
2
Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Trop. Med. Infect. Dis. 2023, 8(3), 181; https://doi.org/10.3390/tropicalmed8030181
Submission received: 20 February 2023 / Revised: 17 March 2023 / Accepted: 18 March 2023 / Published: 20 March 2023
(This article belongs to the Special Issue Advances in Diagnosis, Epidemiology and Control on Soil-Transmitted Helminth (STH) Infections - Volume II)
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Abstract

Strongyloides stercoralis infection is generally asymptomatic or mildly symptomatic, but in the immunosuppressed host, it is associated with more severe and complicated forms with a worse prognosis. S. stercoralis seroprevalence was studied in 256 patients before receiving immunosuppressive treatment (before kidney transplantation or starting biological treatments). As a control group, serum bank data of 642 individuals representative of the population of the Canary Islands were retrospectively analyzed. To avoid false positives due to cross-reactivity with other similar helminth antigens present in the study area, IgG antibodies to Toxocara spp. and Echinococcus spp. were evaluated in cases positive for Strongyloides. The data show this is a prevalent infection: 1.1% of the Canarian population, 2.38% of Canarian individuals awaiting organ transplants and 4.8% of individuals about to start biological agents. On the other hand, strongyloidiasis can remain asymptomatic (as observed in our study population). There are no indirect data, such as country of origin or eosinophilia, to help raise suspicion of the disease. In summary, our study suggests that screening for S. stercoralis infection should be performed in patients who receive immunosuppressive treatment for solid organ transplantation or biological agents, in line with previous publications.
Keywords: Strongyloides stercoralis; kidney transplantation; biological therapies Strongyloides stercoralis; kidney transplantation; biological therapies

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MDPI and ACS Style

Carranza-Rodríguez, C.; López-Delgado, L.; Granados-Magan, Á.; Pérez-Arellano, J.-L. Seroprevalence of Strongyloides stercoralis in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain). Trop. Med. Infect. Dis. 2023, 8, 181. https://doi.org/10.3390/tropicalmed8030181

AMA Style

Carranza-Rodríguez C, López-Delgado L, Granados-Magan Á, Pérez-Arellano J-L. Seroprevalence of Strongyloides stercoralis in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain). Tropical Medicine and Infectious Disease. 2023; 8(3):181. https://doi.org/10.3390/tropicalmed8030181

Chicago/Turabian Style

Carranza-Rodríguez, Cristina, Laura López-Delgado, Álvaro Granados-Magan, and José-Luis Pérez-Arellano. 2023. "Seroprevalence of Strongyloides stercoralis in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain)" Tropical Medicine and Infectious Disease 8, no. 3: 181. https://doi.org/10.3390/tropicalmed8030181

APA Style

Carranza-Rodríguez, C., López-Delgado, L., Granados-Magan, Á., & Pérez-Arellano, J.-L. (2023). Seroprevalence of Strongyloides stercoralis in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain). Tropical Medicine and Infectious Disease, 8(3), 181. https://doi.org/10.3390/tropicalmed8030181

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