Next Article in Journal
Monitoring of the Sensitivity In Vivo of Plasmodium falciparum to Artemether-Lumefantrine in Mali
Next Article in Special Issue
Assessing the Risk of Exotic Mosquito Incursion through an International Seaport, Newcastle, NSW, Australia
Previous Article in Journal
Travel-Related Antimicrobial Resistance: A Systematic Review
Previous Article in Special Issue
Risk Factors for Elevated Serum Lipopolysaccharide in Acute Dengue and Association with Clinical Disease Severity
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
TropicalMed
Volume 6
Issue 1
10.3390/tropicalmed6010012
tropicalmed-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand

by
Hisham A Imad
1,2,3,*,
Juthamas Phadungsombat
1,
Emi E Nakayama
1,2,
Sajikapon Kludkleeb
3,
Wasin Matsee
3,
Thitiya Ponam
3,
Keita Suzuki
2,4,
Pornsawan Leaungwutiwong
5,
Watcharapong Piyaphanee
3,
Weerapong Phumratanaprapin
3 and
Tatsuo Shioda
1,2
1
Mahidol-Osaka Center for Infectious Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
2
Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan
3
Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
4
POCT Products Business Unit, TANAKA Kikinzoku Kogyo, Hiratsuka 254-0076, Japan
5
Tropical Medicine Diagnostic Reference Laboratory, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2021, 6(1), 12; https://doi.org/10.3390/tropicalmed6010012
Submission received: 30 December 2020 / Revised: 11 January 2021 / Accepted: 15 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue Epidemiology of Dengue: Past, Present and Future (Volume II))
Browse Figures
Versions Notes

Abstract

Chikungunya virus is an Alphavirus belonging to the family Togaviridae that is transmitted to humans by an infected Aedes mosquito. Patients develop fever, inflammatory arthritis, and rash during the acute stage of infection. Although the illness is self-limiting, atypical and severe cases are not uncommon, and 60% may develop chronic symptoms that persist for months or even for longer durations. Having a distinct periodical epidemiologic outbreak pattern, chikungunya virus reappeared in Thailand in December 2018. Here, we describe a cohort of acute chikungunya patients who had presented to the Bangkok Hospital for Tropical Diseases during October 2019. Infection was detected by a novel antigen kit and subsequently confirmed by real-time RT-PCR using serum collected at presentation to the Fever Clinic. Other possible acute febrile illnesses such as influenza, dengue, and malaria were excluded. We explored the sequence of clinical manifestations at presentation during the acute phase and associated the viral load with the clinical findings. Most of the patients were healthy individuals in their forties. Fever and arthralgia were the predominant clinical manifestations found in this patient cohort, with a small proportion of patients with systemic symptoms. Higher viral loads were associated with arthralgia, and arthralgia with the involvement of the large joints was more common in female patients.
Keywords: Alphavirus; chikungunya virus; East Central South African lineage; Indian Ocean sub-lineage; acute febrile illness; viremia; arthritides Alphavirus; chikungunya virus; East Central South African lineage; Indian Ocean sub-lineage; acute febrile illness; viremia; arthritides

Share and Cite

MDPI and ACS Style

Imad, H.A.; Phadungsombat, J.; Nakayama, E.E.; Kludkleeb, S.; Matsee, W.; Ponam, T.; Suzuki, K.; Leaungwutiwong, P.; Piyaphanee, W.; Phumratanaprapin, W.; et al. Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Trop. Med. Infect. Dis. 2021, 6, 12. https://doi.org/10.3390/tropicalmed6010012

AMA Style

Imad HA, Phadungsombat J, Nakayama EE, Kludkleeb S, Matsee W, Ponam T, Suzuki K, Leaungwutiwong P, Piyaphanee W, Phumratanaprapin W, et al. Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Tropical Medicine and Infectious Disease. 2021; 6(1):12. https://doi.org/10.3390/tropicalmed6010012

Chicago/Turabian Style

Imad, Hisham A, Juthamas Phadungsombat, Emi E Nakayama, Sajikapon Kludkleeb, Wasin Matsee, Thitiya Ponam, Keita Suzuki, Pornsawan Leaungwutiwong, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, and et al. 2021. "Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand" Tropical Medicine and Infectious Disease 6, no. 1: 12. https://doi.org/10.3390/tropicalmed6010012

APA Style

Imad, H. A., Phadungsombat, J., Nakayama, E. E., Kludkleeb, S., Matsee, W., Ponam, T., Suzuki, K., Leaungwutiwong, P., Piyaphanee, W., Phumratanaprapin, W., & Shioda, T. (2021). Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Tropical Medicine and Infectious Disease, 6(1), 12. https://doi.org/10.3390/tropicalmed6010012

Article Metrics

Back to TopTop