Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand

Imad, Hisham A; Phadungsombat, Juthamas; Nakayama, Emi E; Kludkleeb, Sajikapon; Matsee, Wasin; Ponam, Thitiya; Suzuki, Keita; Leaungwutiwong, Pornsawan; Piyaphanee, Watcharapong; Phumratanaprapin, Weerapong; Shioda, Tatsuo

doi:10.3390/tropicalmed6010012

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand

Hisham A Imad

^1,2,3,*

Juthamas Phadungsombat

^1,2

³,

³,

^2,4,

Pornsawan Leaungwutiwong

⁵,

Watcharapong Piyaphanee

³,

Weerapong Phumratanaprapin

³ and

Tatsuo Shioda

^1,2

Mahidol-Osaka Center for Infectious Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand

Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan

Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand

⁴

POCT Products Business Unit, TANAKA Kikinzoku Kogyo, Hiratsuka 254-0076, Japan

⁵

Tropical Medicine Diagnostic Reference Laboratory, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand

Author to whom correspondence should be addressed.

Trop. Med. Infect. Dis. 2021, 6(1), 12; https://doi.org/10.3390/tropicalmed6010012

Received: 30 December 2020 / Revised: 11 January 2021 / Accepted: 15 January 2021 / Published: 21 January 2021

(This article belongs to the Special Issue Epidemiology of Dengue: Past, Present and Future (Volume II))

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

Chikungunya virus is an Alphavirus belonging to the family Togaviridae that is transmitted to humans by an infected Aedes mosquito. Patients develop fever, inflammatory arthritis, and rash during the acute stage of infection. Although the illness is self-limiting, atypical and severe cases are not uncommon, and 60% may develop chronic symptoms that persist for months or even for longer durations. Having a distinct periodical epidemiologic outbreak pattern, chikungunya virus reappeared in Thailand in December 2018. Here, we describe a cohort of acute chikungunya patients who had presented to the Bangkok Hospital for Tropical Diseases during October 2019. Infection was detected by a novel antigen kit and subsequently confirmed by real-time RT-PCR using serum collected at presentation to the Fever Clinic. Other possible acute febrile illnesses such as influenza, dengue, and malaria were excluded. We explored the sequence of clinical manifestations at presentation during the acute phase and associated the viral load with the clinical findings. Most of the patients were healthy individuals in their forties. Fever and arthralgia were the predominant clinical manifestations found in this patient cohort, with a small proportion of patients with systemic symptoms. Higher viral loads were associated with arthralgia, and arthralgia with the involvement of the large joints was more common in female patients. View Full-Text

Keywords: Alphavirus; chikungunya virus; East Central South African lineage; Indian Ocean sub-lineage; acute febrile illness; viremia; arthritides

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

Supplementary File 1:
PDF-Document (PDF, 399 KiB)

Share and Cite

MDPI and ACS Style

Imad, H.A.; Phadungsombat, J.; Nakayama, E.E.; Kludkleeb, S.; Matsee, W.; Ponam, T.; Suzuki, K.; Leaungwutiwong, P.; Piyaphanee, W.; Phumratanaprapin, W.; Shioda, T. Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Trop. Med. Infect. Dis. 2021, 6, 12. https://doi.org/10.3390/tropicalmed6010012

AMA Style

Imad HA, Phadungsombat J, Nakayama EE, Kludkleeb S, Matsee W, Ponam T, Suzuki K, Leaungwutiwong P, Piyaphanee W, Phumratanaprapin W, Shioda T. Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Tropical Medicine and Infectious Disease. 2021; 6(1):12. https://doi.org/10.3390/tropicalmed6010012

Chicago/Turabian Style

Imad, Hisham A., Juthamas Phadungsombat, Emi E. Nakayama, Sajikapon Kludkleeb, Wasin Matsee, Thitiya Ponam, Keita Suzuki, Pornsawan Leaungwutiwong, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, and Tatsuo Shioda. 2021. "Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand" Tropical Medicine and Infectious Disease 6, no. 1: 12. https://doi.org/10.3390/tropicalmed6010012

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Author Biographies

Further Information

Guidelines

MDPI Initiatives

Follow MDPI