Next Article in Journal
Q Fever in the First Trimester: A Case Report from Northern Rural New South Wales
Next Article in Special Issue
Marine Microbiome as a Source of Antimalarials
Previous Article in Journal
The One Health Approach—Why Is It So Important?
Previous Article in Special Issue
Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection
Open AccessReview

Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance

Departments of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington, DC 20057, USA
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2019, 4(2), 89; https://doi.org/10.3390/tropicalmed4020089
Received: 18 April 2019 / Revised: 21 May 2019 / Accepted: 24 May 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Drug Discovery and Development for Tropical Diseases)
The molecular pharmacology of artemisinin (ART)-based antimalarial drugs is incompletely understood. Clinically, these drugs are used in combination with longer lasting partner drugs in several different artemisinin combination therapies (ACTs). ACTs are currently the standard of care against Plasmodium falciparum malaria across much of the world. A harbinger of emerging artemisinin resistance (ARTR), known as the delayed clearance phenotype (DCP), has been well documented in South East Asia (SEA) and is beginning to affect the efficacy of some ACTs. Though several genetic mutations have been associated with ARTR/DCP, a molecular mechanism remains elusive. This paper summarizes our current understanding of ART molecular pharmacology and hypotheses for ARTR/DCP. View Full-Text
Keywords: heme adduct; PfPI3KIII; artemisinin target heme adduct; PfPI3KIII; artemisinin target
Show Figures

Figure 1

MDPI and ACS Style

Heller, L.E.; Roepe, P.D. Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance. Trop. Med. Infect. Dis. 2019, 4, 89.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop