The Unique Life Cycle of Strongyloides stercoralis and Implications for Public Health Action
AbstractStrongyloides stercoralis has one of the most complex life cycles of the human-infecting nematodes. A common misconception in medical and public health professions is that S. stercoralis in its biology is akin to other intestinal nematodes, such as the hookworms. Despite original evidence provided by medical and veterinary research about this unique helminth, many assumptions have entered the scientific literature. This helminth is set apart from others that commonly affect humans by (a) the internal autoinfective cycle with autoinfective larvae randomly migrating through tissue, parthenogenesis, and the potential for lifelong infection in the host, the profound pathology occurring in hyperinfection and systemic manifestations of strongyloidiasis, and (b) a limited external cycle with a single generation of free-living adults. This paper aims to review and discuss original research on the unique life cycle of S. stercoralis that distinguishes it from other helminths and highlight areas where increased understanding of the parasite’s biology might lead to improved public health prevention and control strategies. View Full-Text
- Supplementary File 1:
ZIP-Document (ZIP, 35419 KB)
A printed edition of this Special Issue is available here.
Share & Cite This Article
Page, W.; Judd, J.A.; Bradbury, R.S. The Unique Life Cycle of Strongyloides stercoralis and Implications for Public Health Action. Trop. Med. Infect. Dis. 2018, 3, 53.
Page W, Judd JA, Bradbury RS. The Unique Life Cycle of Strongyloides stercoralis and Implications for Public Health Action. Tropical Medicine and Infectious Disease. 2018; 3(2):53.Chicago/Turabian Style
Page, Wendy; Judd, Jenni A.; Bradbury, Richard S. 2018. "The Unique Life Cycle of Strongyloides stercoralis and Implications for Public Health Action." Trop. Med. Infect. Dis. 3, no. 2: 53.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.