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A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow
Open AccessReview

Scrub Typhus: No Longer Restricted to the Tsutsugamushi Triangle

Viral and Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2018, 3(1), 11;
Received: 1 December 2017 / Revised: 11 January 2018 / Accepted: 21 January 2018 / Published: 25 January 2018
(This article belongs to the Special Issue The Past and Present Threat of Rickettsial Diseases)
PDF [842 KB, uploaded 25 January 2018]


Scrub typhus is the most important rickettsial disease in the world. Its previous endemic region was considered to be in Asia, Australia and islands in the Indian and Pacific Oceans; this area was referred to as the Tsutsugamushi Triangle. Accumulation of serological, molecular, genetic, and culture data have shown that not only is scrub typhus not limited to the Tsutsugamushi Triangle, but can be caused by orientiae other than Orientia tsutsugamushi. This review describes evidence currently available that will be instrumental to researchers, healthcare providers and medical leaders in developing new research projects, performing diagnosis, and preventing scrub typhus in locations not previously thought to be endemic. View Full-Text
Keywords: scrub typhus; Orientia tsutsugamushi; Tsutsugamushi Triangle; endemic region scrub typhus; Orientia tsutsugamushi; Tsutsugamushi Triangle; endemic region

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Jiang, J.; Richards, A.L. Scrub Typhus: No Longer Restricted to the Tsutsugamushi Triangle. Trop. Med. Infect. Dis. 2018, 3, 11.

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