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Optical Coherence Tomography Reveals Sigmoidal Crystalline Lens Changes during Accommodation

Ophthalmic Research Group, Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
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Vision 2018, 2(3), 33; https://doi.org/10.3390/vision2030033
Received: 20 July 2018 / Revised: 15 August 2018 / Accepted: 17 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Physiological Optics of Accommodation and Presbyopia)
This study aimed to quantify biometric modifications of the anterior segment (AS) during accommodation and to compare them against changes in both accommodative demand and response. Thirty adults, aged 18–25 years were rendered functionally emmetropic with contact lenses. AS optical coherence tomography (AS-OCT) images were captured along the 180° meridian (Visante, Zeiss Meditec, Jena, Germany) under stimulated accommodative demands (0–4 D). Images were analysed and lens thickness (LT) was measured, applying a refractive index correction of 1.00. Accommodative responses were also measured sequentially through a Badal optical system fitted to an autorefractor (Shin Nippon NVision-K 5001, Rexxam, Japan). Data were compared with Dubbelman schematic eye calculations. Significant changes occurred in LT, anterior chamber depth (ACD), lens centroid (i.e., ACD + LT/2), and AS length (ASL = ACD + LT) with accommodation (all p < 0.01). There was no significant change in CT with accommodation (p = 0.81). Measured CT, ACD, and lens centroid values were similar to Dubbelman modelled parameters, however AS-OCT overestimated LT and ASL. As expected, the accommodative response was less than the demand. Interestingly, up until approximately 1.5 D of response (2.0 D demand), the anterior crystalline lens surface appears to be the primary correlate. Beyond this point, the posterior lens surface moves posteriorly resulting in an over-all sigmoidal trajectory. he posterior crystalline lens surface demonstrates a sigmoidal response with increasing accommodative effort. View Full-Text
Keywords: accommodation; crystalline lens; imaging; in-vivo; optical coherence tomography accommodation; crystalline lens; imaging; in-vivo; optical coherence tomography
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Gibson, G.A.; Cruickshank, F.E.; Wolffsohn, J.S.; Davies, L.N. Optical Coherence Tomography Reveals Sigmoidal Crystalline Lens Changes during Accommodation. Vision 2018, 2, 33.

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