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A Retrospective Analysis of the Effect of Subretinal Hyper-Reflective Material and Other Morphological Features of Neovascular Age-Related Macular Degeneration on Visual Acuity Outcomes in Eyes Treated with Intravitreal Aflibercept over One Year
Open AccessReview

New Therapies of Neovascular AMD beyond Anti-VEGF Injections

1
University of Nevada, Reno School of Medicine, Reno, NV 89557, USA
2
Sierra Eye Associates, Reno, NV 89502, USA
*
Author to whom correspondence should be addressed.
Vision 2018, 2(1), 15; https://doi.org/10.3390/vision2010015
Received: 22 January 2018 / Revised: 4 February 2018 / Accepted: 12 March 2018 / Published: 19 March 2018
(This article belongs to the Special Issue Age-Related Macular Degeneration)
Neovascular age-related macular degeneration is a leading cause of vision loss among the aging population. The current standard of care to treat neovascular age-related macular degeneration is inhibiting vascular endothelial growth factor (VEGF) through intravitreal injections. Recent studies have demonstrated that the tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2 (Tie2) pathway also plays a critical role in angiogenesis and vascular stability. Additionally, newly developed treatment delivery systems have been designed to greatly reduce the frequency of injections. In targeting the Tie2 pathway and utilizing a sustained release delivery system, patients may experience improved visual outcomes and a reduced burden of treatment. View Full-Text
Keywords: age-related macular degeneration; Tie2; anti-VEGF; RG7716; ranibizumab age-related macular degeneration; Tie2; anti-VEGF; RG7716; ranibizumab
MDPI and ACS Style

Gahn, G.M.; Khanani, A.M. New Therapies of Neovascular AMD beyond Anti-VEGF Injections. Vision 2018, 2, 15.

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