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Open AccessPatent Summary

Chronometric Quantitation of Analytes in Paper-Based Microfluidic Devices (MicroPADs) via Enzymatic Degradation of a Metastable Biomatrix

1
Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, CA 93407, USA
2
Department of Chemistry & Biochemistry, California Polytechnic State University, San Luis Obispo, CA 93407, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Inventions 2019, 4(3), 48; https://doi.org/10.3390/inventions4030048
Received: 30 June 2019 / Revised: 10 August 2019 / Accepted: 15 August 2019 / Published: 21 August 2019
(This article belongs to the Special Issue Microfluidic Devices)
The following article summarizes United States Patent Application No. US20180052155A1, titled ‘Assay Devices and Methods’ (filed 16 August 2016, published 22 February 2018). While lateral flow assays (LFAs) have revolutionized point-of-care diagnostics by enabling accurate, inexpensive, and rapid detection of biomarkers, they typically do not provide quantitative results. Hence, there is a significant need for quantitative assays at the point of care. This patent summary describes a novel method of chronometric biomarker quantitation via enzymatic degradation of a metastable gelatin-based biomatrix, principally suited for use in paper-based microfluidic devices (microPADs). This new quantitation mechanism was designed to meet the ASSURED criteria for point-of-care diagnostic devices laid forth by the World Health Organization and may ultimately provide increased access to healthcare, at a significantly reduced cost, around the world. View Full-Text
Keywords: microfluidic paper-based analytical device; µPAD; microPAD; point-of-care; diagnostics; microfluidics; wax printing; immunoassays; analytical chemistry microfluidic paper-based analytical device; µPAD; microPAD; point-of-care; diagnostics; microfluidics; wax printing; immunoassays; analytical chemistry
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MDPI and ACS Style

Jangid, A.R.; Strong, E.B.; Escamilla, E.; Lore, B.A.; Tod, N.J.; Thiel, R.; Martinez, A.W.; Martinez, N.W. Chronometric Quantitation of Analytes in Paper-Based Microfluidic Devices (MicroPADs) via Enzymatic Degradation of a Metastable Biomatrix. Inventions 2019, 4, 48.

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