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Therapeutic Potential of Iridoid Derivatives: Patent Review

1
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Salle), Germany
2
Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, South Africa
3
Department of Chemistry, The Islamia University of Bahawalpur, 63100 Bahawalpur, Pakistan
4
Department of Clinical Sciences, Biomedical Centre – BMC, Lund University Hospital, 223 62 Lund, Sweden
5
Department of Chemistry, Government Sadiq College Women University Bahawalpur, Bahawalpur 63100, Pakistan
*
Author to whom correspondence should be addressed.
Inventions 2019, 4(2), 29; https://doi.org/10.3390/inventions4020029
Received: 31 March 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 16 May 2019
PDF [368 KB, uploaded 16 May 2019]

Abstract

Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophulariaceae, and Verbenaceae. Furthermore, iridoids have the potential to form conjugates with other anticancer, antidiabetic, antileishmanial, and antimalarial drugs which synergistically have the potential to increase their effects. Additionally, future research should focus on the synthesis of halo analogs as well as preparing homo dimers or heterodimers of iridoids, since these might quite conceivably possess an increased bioactivity.
Keywords: iridoids; cytotoxic; antidiabetic; anti-inflammatory; antimalarial; trypanosomiasis iridoids; cytotoxic; antidiabetic; anti-inflammatory; antimalarial; trypanosomiasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hussain, H.; Green, I.R.; Saleem, M.; Raza, M.L.; Nazir, M. Therapeutic Potential of Iridoid Derivatives: Patent Review. Inventions 2019, 4, 29.

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