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PDMS-Based Microfluidic Devices for Cell Culture

Institute for Microelectronics and Microsystems, National Research Council, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Inventions 2018, 3(3), 65;
Received: 26 July 2018 / Revised: 1 September 2018 / Accepted: 4 September 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Microfluidics and Nanofluidics)
PDF [797 KB, uploaded 6 September 2018]


Microfluidic technology has affirmed itself as a powerful tool in medical and biological research by offering the possibility of managing biological samples in tiny channels and chambers. Among the different applications, the use of microfluidics for cell cultures has attracted much interest from scientists worldwide. Traditional cell culture methods need high quantities of samples and reagents that are strongly reduced in miniaturized systems. In addition, the microenvironment is better controlled by scaling down. In this paper, we provide an overview of the aspects related to the design of a novel microfluidic culture chamber, the fabrication approach based on polydimethylsiloxane (PDMS) soft-lithography, and the most critical issues in shrinking the size of the system. View Full-Text
Keywords: microfluidics; lab-on-a-chip; cell culture microfluidics; lab-on-a-chip; cell culture

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Torino, S.; Corrado, B.; Iodice, M.; Coppola, G. PDMS-Based Microfluidic Devices for Cell Culture. Inventions 2018, 3, 65.

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