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Instruments 2018, 2(2), 8; https://doi.org/10.3390/instruments2020008

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

1
Nuclear Medicine Department, School of Health, Polytechnic Institute of Porto, 4200-072 Porto, Portugal
2
Health and Environment Research Center (CISA), Polytechnic Institute of Porto, 4200-072 Porto, Portugal
3
Isótopos para Diagnóstico e Terapêutica (IsoPor), S.A., 4445-526 Ermesinde, Portugal
4
Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, 3000-548 Coimbra, Portugal
5
Coimbra Health School, Polytechnic Institute of Coimbra , 3046-854 Coimbra, Portugal
6
Physics Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
7
Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), University of Coimbra, 3030-788 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Received: 2 May 2018 / Revised: 28 May 2018 / Accepted: 31 May 2018 / Published: 3 June 2018
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
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Abstract

Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18F, 11C, and, more recently, 68Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β+ endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging. View Full-Text
Keywords: cyclotron; PET; titanium-45; unconventional radionuclides cyclotron; PET; titanium-45; unconventional radionuclides
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Costa, P.; Metello, L.F.; Alves, F.; Duarte Naia, M. Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications. Instruments 2018, 2, 8.

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