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Open AccessReview

A Light Wand to Untangle the Myocardial Cell Network

1
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128 Padova, Italy
2
Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35122 Padova, Italy
3
Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
4
CNR Institute of Neuroscience, Viale G. Colombo 3, 35121 Padova, Italy
*
Author to whom correspondence should be addressed.
Methods Protoc. 2019, 2(2), 34; https://doi.org/10.3390/mps2020034
Received: 21 March 2019 / Revised: 24 April 2019 / Accepted: 28 April 2019 / Published: 3 May 2019
The discovery of optogenetics has revolutionized research in neuroscience by providing the tools for noninvasive, cell-type selective modulation of membrane potential and cellular function in vitro and in vivo. Rhodopsin-based optogenetics has later been introduced in experimental cardiology studies and used as a tool to photoactivate cardiac contractions or to identify the sites, timing, and location most effective for defibrillating impulses to interrupt cardiac arrhythmias. The exploitation of cell-selectivity of optogenetics, and the generation of model organisms with myocardial cell type targeted expression of opsins has started to yield novel and sometimes unexpected notions on myocardial biology. This review summarizes the main results, the different uses, and the prospective developments of cardiac optogenetics. View Full-Text
Keywords: heart; optogenetics; Channelrhodopsin-2; arrhythmias; heart network heart; optogenetics; Channelrhodopsin-2; arrhythmias; heart network
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Zaglia, T.; Di Bona, A.; Mongillo, M. A Light Wand to Untangle the Myocardial Cell Network. Methods Protoc. 2019, 2, 34.

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