Next Article in Journal
Preactivation Crosslinking—An Efficient Method for the Oriented Immobilization of Antibodies
Previous Article in Journal
Cell-Free Metabolic Engineering: Recent Developments and Future Prospects
Previous Article in Special Issue
Large Scale Double-Path Illumination System with Split Field of View for the All-Optical Study of Inter-and Intra-Hemispheric Functional Connectivity on Mice
Open AccessReview

A Light Wand to Untangle the Myocardial Cell Network

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128 Padova, Italy
Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35122 Padova, Italy
Veneto Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
CNR Institute of Neuroscience, Viale G. Colombo 3, 35121 Padova, Italy
Author to whom correspondence should be addressed.
Methods Protoc. 2019, 2(2), 34;
Received: 21 March 2019 / Revised: 24 April 2019 / Accepted: 28 April 2019 / Published: 3 May 2019
The discovery of optogenetics has revolutionized research in neuroscience by providing the tools for noninvasive, cell-type selective modulation of membrane potential and cellular function in vitro and in vivo. Rhodopsin-based optogenetics has later been introduced in experimental cardiology studies and used as a tool to photoactivate cardiac contractions or to identify the sites, timing, and location most effective for defibrillating impulses to interrupt cardiac arrhythmias. The exploitation of cell-selectivity of optogenetics, and the generation of model organisms with myocardial cell type targeted expression of opsins has started to yield novel and sometimes unexpected notions on myocardial biology. This review summarizes the main results, the different uses, and the prospective developments of cardiac optogenetics. View Full-Text
Keywords: heart; optogenetics; Channelrhodopsin-2; arrhythmias; heart network heart; optogenetics; Channelrhodopsin-2; arrhythmias; heart network
Show Figures

Figure 1

MDPI and ACS Style

Zaglia, T.; Di Bona, A.; Mongillo, M. A Light Wand to Untangle the Myocardial Cell Network. Methods Protoc. 2019, 2, 34.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop