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Methods Protoc. 2018, 1(2), 11; https://doi.org/10.3390/mps1020011

Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India

1
The INCLEN Trust International, New Delhi 110020, India
2
University Children’s Hospital (UKBB), University of Basel, 4056 Basel, Switzerland
3
Coordinator, Brighton Collaboration Foundation, 4056 Basel, Switzerland
4
Department of Essential Medicines and Health Products, World Health Organization, 1211 Geneva 27, Switzerland
*
Author to whom correspondence should be addressed.
Received: 6 February 2018 / Revised: 19 March 2018 / Accepted: 19 March 2018 / Published: 22 March 2018
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Abstract

India has recently introduced a rotavirus vaccine under a universal immunization program. There is limited information on intussusception, an adverse event, following immunization in children from India. We are conducting sentinel surveillance for intussusception in children aged under two years at 19 hospitals. The sentinel sites’ selection followed a multistage process. The surveillance combines retrospective surveillance for 69 months and prospective surveillance for 18 months. The suspected intussusception cases shall be reviewed for capturing confirmed cases and detailed data collection and classification according to Brighton Collaboration criteria. Data shall be analysed to describe epidemiology, trends, regional and seasonal variations, clinical profiles, management modalities, and outcomes of intussusception. The combination of prospective and retrospective surveillance shall be informative about the trend of intussusception over the last seven years in India. At four sites where rotavirus vaccines have been introduced, the change in intussusception trends shall be documented. The potential association with rotavirus vaccines and other vaccines shall be assessed using case-control and self-controlled case series methodology. Results are forthcoming. The results shall support the national vaccine safety surveillance effort by providing baseline estimates of intussusception for continued monitoring. The surveillance protocol and site selection processes shall inform similar vaccine-safety surveillance in India and other developing countries. View Full-Text
Keywords: intussusception; retrospective; prospective; surveillance; rotavirus vaccine intussusception; retrospective; prospective; surveillance; rotavirus vaccine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Das, M.K.; Arora, N.K.; Bonhoeffer, J.; Zuber, P.L.F.; Maure, C.G. Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India. Methods Protoc. 2018, 1, 11.

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