Next Article in Journal
Paramyxovirus Infections in Ex Vivo Lung Slice Cultures of Different Host Species
Previous Article in Journal
High Performance Liquid Chromatography Separation of Epigenetic Cytosine Variants
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessProtocol

Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India

The INCLEN Trust International, New Delhi 110020, India
University Children’s Hospital (UKBB), University of Basel, 4056 Basel, Switzerland
Coordinator, Brighton Collaboration Foundation, 4056 Basel, Switzerland
Department of Essential Medicines and Health Products, World Health Organization, 1211 Geneva 27, Switzerland
Author to whom correspondence should be addressed.
Methods Protoc. 2018, 1(2), 11;
Received: 6 February 2018 / Revised: 19 March 2018 / Accepted: 19 March 2018 / Published: 22 March 2018
PDF [539 KB, uploaded 3 May 2018]


India has recently introduced a rotavirus vaccine under a universal immunization program. There is limited information on intussusception, an adverse event, following immunization in children from India. We are conducting sentinel surveillance for intussusception in children aged under two years at 19 hospitals. The sentinel sites’ selection followed a multistage process. The surveillance combines retrospective surveillance for 69 months and prospective surveillance for 18 months. The suspected intussusception cases shall be reviewed for capturing confirmed cases and detailed data collection and classification according to Brighton Collaboration criteria. Data shall be analysed to describe epidemiology, trends, regional and seasonal variations, clinical profiles, management modalities, and outcomes of intussusception. The combination of prospective and retrospective surveillance shall be informative about the trend of intussusception over the last seven years in India. At four sites where rotavirus vaccines have been introduced, the change in intussusception trends shall be documented. The potential association with rotavirus vaccines and other vaccines shall be assessed using case-control and self-controlled case series methodology. Results are forthcoming. The results shall support the national vaccine safety surveillance effort by providing baseline estimates of intussusception for continued monitoring. The surveillance protocol and site selection processes shall inform similar vaccine-safety surveillance in India and other developing countries. View Full-Text
Keywords: intussusception; retrospective; prospective; surveillance; rotavirus vaccine intussusception; retrospective; prospective; surveillance; rotavirus vaccine

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Das, M.K.; Arora, N.K.; Bonhoeffer, J.; Zuber, P.L.F.; Maure, C.G. Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India. Methods Protoc. 2018, 1, 11.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Methods Protoc. EISSN 2409-9279 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top