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Newborn Screening for Sickle Cell Disease in the Caribbean: An Update of the Present Situation and of the Disease Prevalence

1
Caribbean Institute for Health Research—Sickle Cell Unit, The University of the West Indies, Mona, Kingston 7, Jamaica
2
Laboratory of Molecular Genetics, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe
3
Referral Center for Sickle Cell Disease, Department of Pediatrics, Academic Hospital of Martinique, 97261 Fort de France, Martinique, France
4
Referral Center for Sickle Cell Disease, Department of Pediatric Medicine and Surgery, Andrée Rosemon General Hospital, 97306 Cayenne, French Guiana, France
5
National Center of Medical Genetics, 11300 La Habana, Cuba
6
Paediatric Department, Scarborough General Hospital, 00000 Scarborough, Tobago
7
Referral Center for Sickle Cell Disease, Sickle Cell Unit, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe, France
8
UMR Inserm 1134 Biologie Intégrée du Globule Rouge, Inserm/Université Paris Diderot—Université Sorbonne Paris Cité/INTS/Université des Antilles, Hôpital Ricou, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe
9
Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, 75015 Paris, France
10
CAribbean Network of REsearchers on Sickle Cell Disease and Thalassemia, UMR Inserm 1134, Hôpital Ricou, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Neonatal Screen. 2019, 5(1), 5; https://doi.org/10.3390/ijns5010005
Received: 13 November 2018 / Revised: 7 December 2018 / Accepted: 1 January 2019 / Published: 8 January 2019
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PDF [247 KB, uploaded 8 January 2019]

Abstract

The region surrounding the Caribbean Sea is predominantly composed of island nations for its Eastern part and the American continental coast on its Western part. A large proportion of the population, particularly in the Caribbean islands, traces its ancestry to Africa as a consequence of the Atlantic slave trade during the XVI–XVIII centuries. As a result, sickle cell disease has been largely introduced in the region. Some Caribbean countries and/or territories, such as Jamaica and the French territories, initiated newborn screening (NBS) programs for sickle cell disease more than 20 years ago. They have demonstrated the major beneficial impact on mortality and morbidity resulting from early childhood care. However, similar programs have not been implemented in much of the region. This paper presents an update of the existing NBS programs and the prevalence of sickle cell disease in the Caribbean. It demonstrates the impact of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia (CAREST) on the extension of these programs. The presented data illustrate the importance of advocacy in convincing policy makers of the feasibility and benefit of NBS for sickle cell disease when coupled to early care. View Full-Text
Keywords: sickle cell disease; newborn screening; Caribbean sickle cell disease; newborn screening; Caribbean
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Knight-Madden, J.; Lee, K.; Elana, G.; Elenga, N.; Marcheco-Teruel, B.; Keshi, N.; Etienne-Julan, M.; King, L.; Asnani, M.; Romana, M.; Hardy-Dessources, M.-D. Newborn Screening for Sickle Cell Disease in the Caribbean: An Update of the Present Situation and of the Disease Prevalence. Int. J. Neonatal Screen. 2019, 5, 5.

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