Pulse Oximetry Values in Newborns with Critical Congenital Heart Disease upon ICU Admission at Altitude
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Descriptive Analysis of Study Cohort
3.2. Secondary Analysis: Hypothetical Screening of Study Cohort
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Characteristics | Study Subjects (n = 158) | Excluded Subjects (n = 56) | p-Value |
---|---|---|---|
Gestational age, weeks (range) | 38.2 ± 2.4 (29–45) | 38.3 ± 2.4 (30–41.3) | 0.379 |
Birth weight, g (range) | 2988.7 ± 579.3 (1230–4165) | 3071.0 ± 671.7 (960–4780) | 0.277 |
Male gender, n (%) | 101 (63.9) | 35 (62.5) | 0.849 |
Race, n (%) | 0.470 | ||
White/Caucasian | 111 (70.3) | 37 (66.1) | |
Black/African American | 10 (6.3) | 3 (5.4) | |
Hawaiian/Pacific Islander | 1 (0.6) | 0 (0) | |
Asian | 1 (0.6) | 1 (1.8) | |
American Indian/Alaskan Native | 3 (3.2) | 1 (1.8) | |
Other | 26 (16.5) | 9 (16.1) | |
Not specified | 4 (2.5) | 5 (8.9) | |
Ethnicity, n (%) | 0.088 | ||
Hispanic/Latino | 54 (34.2) | 15 (26.8) | |
Not Hispanic/Latino | 100 (63.3) | 36 (64.3) | |
Not specified | 4 (2.5) | 5 (8.9) | |
Apgar score, score (range) | |||
1 min | 7 ± 2 (0–9) | 7 ± 2 (2–8) | 0.409 |
5 min | 8 ± 1 (0–9) | 8 ± 1 (4–9) | 0.212 |
Prenatal diagnosis of CCHD, n (%) | 84 (53.2) | 20 (35.7) | 0.152 |
Family history of CCHD, n (%) | 18 (11.4) | 3 (5.4) | 0.361 |
Genetic diagnosis, n (%) | 0.825 | ||
Down syndrome | 2 (1.3) | 0 (0) | |
22q11 deletion | 6 (3.8) | 1 (1.8) | |
None specified | 150 (94.9) | 50 (89.3) | |
CCHD diagnosis, n (%) | 0.002 * | ||
HLHS | 48 (30.4) | 17 (30.4) | |
TOF | 34 (21.5) | 5 (8.9) | |
TGA | 30 (19.0) | 26 (46.4) | |
TA | 13 (8.2) | 2 (3.6) | |
TAPVR | 10 (6.3) | 5 (8.9) | |
TVA | 10 (6.3) | 0 (0) | |
PA/IVS | 7 (4.4) | 1 (1.8) | |
Combination of above | 6 (3.8) | 0 (0) | |
Maternal age, years (range) | 28.1 ± 5.8 (15–42) | 26.5 ± 6.0 (15–41) | 0.089 |
Maternal diabetes status, n (%) | 0.272 | ||
Diabetes (Type I or Type II) | 7 (4.5) | 0 (0) | |
Gestational diabetes | 6 (3.8) | 3 (5.4) | |
Not diabetic | 144 (91.7) | 53 (94.6) |
No Support | PGE | Oxygen | Both PGE and Oxygen | ||
---|---|---|---|---|---|
24-hours | Pre-ductal | 90.3 ± 7.7 (77–100) (n = 7) | 88.6 ± 7.3 (75–100) (n = 30) | 86.6 ± 4.3 (80–95) (n = 14) | 85.2 ± 7.6 (70–98) (n = 36) |
Post-ductal | 89.4 ± 5.4 (80–97) (n = 14) | 87.8 ± 6.3 (73–99) (n = 33) | 88.9 ± 6.0 (78–97) (n = 18) | 86.8 ± 6.6 (67–100) (n = 42) | |
28-hours | Pre-ductal | 88.0 ± 5.0 (81–95) (n = 7) | 88.3 ± 6.8 (74–100) (n = 28) | 84.6 ± 7.1 (72–96) (n = 18) | 86.1 ± 7.8 (53–96) (n = 34) |
Post-ductal | 90.3 ± 6.2 (78–100) (n = 14) | 88.5 ± 7.4 (70–100) (n = 35) | 85.7 ± 6.7 (72–95) (n = 20) | 86.2 ± 7.6 (68–100) (n = 43) | |
36-hours | Pre-ductal | 89.0 ± 9.2 (77–99) (n = 4) | 88.4 ± 5.0 (76–100) (n = 33) | 86.3 ± 8.0 (65–98) (n = 16) | 85.5 ± 8.9 (65–100) (n = 38) |
Post-ductal | 90.0 ± 4.9 (82–100) (n = 15) | 90.2 ± 4.4 (79–98) (n = 46) | 88.9 ± 7.0 (72–100) (n = 22) | 86.1 ± 8.2 (68–99) (n = 46) | |
48-hours | Pre-ductal | 91.0 ± 5.3 (80–97) (n = 8) | 90.4 ± 6.4 (70–100) (n = 42) | 89.8 ± 4.5 (81–98) (n = 13) | 87.4 ± 7.3 * (67–100) (n = 35) |
Post-ductal | 90.3 ± 6.4 (75–100) (n = 21) | 90.5 ± 5.2 (75–99) (n = 51) | 91.5 ± 4.8 (80–97) (n = 20) | 86.3 ± 7.0 * (63–100) (n = 45) |
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Kim, J.S.; Ariefdjohan, M.W.; Sontag, M.K.; Rausch, C.M. Pulse Oximetry Values in Newborns with Critical Congenital Heart Disease upon ICU Admission at Altitude. Int. J. Neonatal Screen. 2018, 4, 30. https://doi.org/10.3390/ijns4040030
Kim JS, Ariefdjohan MW, Sontag MK, Rausch CM. Pulse Oximetry Values in Newborns with Critical Congenital Heart Disease upon ICU Admission at Altitude. International Journal of Neonatal Screening. 2018; 4(4):30. https://doi.org/10.3390/ijns4040030
Chicago/Turabian StyleKim, John S., Merlin W. Ariefdjohan, Marci K. Sontag, and Christopher M. Rausch. 2018. "Pulse Oximetry Values in Newborns with Critical Congenital Heart Disease upon ICU Admission at Altitude" International Journal of Neonatal Screening 4, no. 4: 30. https://doi.org/10.3390/ijns4040030