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Article

Visualizing Bioabsorbable Spacer Effectiveness by Confirming the Distal-Tail of Carbon-Ion Beams: First-In-Human Report

1
Department of Radiation Oncology, Shonan Kamakura General Hospital, 1370-1, Okamoto, Kamakura-City 247-8533, Kanagawa, Japan
2
Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi-City 371-8511, Gunma, Japan
3
Gunma University Heavy Ion Medical Center, 3-39-22, Showa-Machi, Maebashi-City 371-8511, Gunma, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Francis Man
Tomography 2022, 8(5), 2339-2346; https://doi.org/10.3390/tomography8050195
Received: 29 July 2022 / Revised: 14 September 2022 / Accepted: 16 September 2022 / Published: 21 September 2022
(This article belongs to the Special Issue Therapy Monitoring Based on PET Imaging)
In particle therapy, bioabsorbable polyglycolic acid (PGA) spacer was developed to reduce the healthy organ irradiation dose, especially in the gastrointestinal tract. The PGA spacer is safe and effective; however, there are no reports that have confirmed whether the PGA spacer which inserted in the body actually stops the carbon-ion (C-ion) beams. Here, we visualized and confirmed that the PGA spacer stops the C-ion beams in the body based on the dose distribution using auto-activation positron emission tomography (AAPET). A 59-year-old dedifferentiated retroperitoneal liposarcoma patient underwent C-ion radiotherapy (C-ion RT) on referral. A month before C-ion RT initiation, the patient underwent PGA spacer placement. Postoperatively, the patient received 4.4 Gy (RBE) per fraction of C-ion RT, followed by AAPET. AAPET revealed lower positron emitter concentrations at the distal tissue ventral to the PGA spacer than in the planning target volume. In observing the efficacy of the PGA spacer, the AAPET images and the average count per second of the positron emitter suggested that the PGA spacer stopped the C-ion beams in the body in accordance with the dose distribution. Therefore, AAPET was useful in confirming the PGA spacer’s effectiveness in this study, and the PGA spacer stopped the C-ion beams. View Full-Text
Keywords: auto-activation positron emission tomography; bioabsorbable polyglycolic acid spacer; carbon-ion radiotherapy; Bragg peak; positron emission tomography auto-activation positron emission tomography; bioabsorbable polyglycolic acid spacer; carbon-ion radiotherapy; Bragg peak; positron emission tomography
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MDPI and ACS Style

Shiba, S.; Okamoto, M.; Sakai, M.; Ohno, T. Visualizing Bioabsorbable Spacer Effectiveness by Confirming the Distal-Tail of Carbon-Ion Beams: First-In-Human Report. Tomography 2022, 8, 2339-2346. https://doi.org/10.3390/tomography8050195

AMA Style

Shiba S, Okamoto M, Sakai M, Ohno T. Visualizing Bioabsorbable Spacer Effectiveness by Confirming the Distal-Tail of Carbon-Ion Beams: First-In-Human Report. Tomography. 2022; 8(5):2339-2346. https://doi.org/10.3390/tomography8050195

Chicago/Turabian Style

Shiba, Shintaro, Masahiko Okamoto, Makoto Sakai, and Tatsuya Ohno. 2022. "Visualizing Bioabsorbable Spacer Effectiveness by Confirming the Distal-Tail of Carbon-Ion Beams: First-In-Human Report" Tomography 8, no. 5: 2339-2346. https://doi.org/10.3390/tomography8050195

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