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Review

Structural, Functional and Neurochemical Cortical Brain Changes Associated with Chronic Low Back Pain

1
Clínica FisioAvanza Delicias, 28045 Madrid, Spain
2
Department of Radiology, Rehabilitation and Physiotherapy, Universidad Complutense de Madrid, 28040 Madrid, Spain
3
Grupo InPhysio, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain
4
Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain
5
Clínica e Investigación en Fisioterapia, Terapia Manual, Punción Seca y Ejercicio Terapéutico, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain
6
VALTRADOFI Research Group, Department of Physiotherapy, Faculty of Health, Universidad Camilo José Cela, Villanueva de la Cañada, 28692 Madrid, Spain
7
Department of Physiotherapy, Faculty of Health, Universidad Camilo José Cela, Villanueva de la Cañada, 28692 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Chad Quarles and Emilio Quaia
Tomography 2022, 8(5), 2153-2163; https://doi.org/10.3390/tomography8050180
Received: 21 June 2022 / Revised: 16 August 2022 / Accepted: 22 August 2022 / Published: 25 August 2022
(This article belongs to the Special Issue Novel Imaging Advances in Physiotherapy)
Chronic low back pain (CLBP) is one of the most prevalent musculoskeletal disorders, being one of the leading contributors to disability worldwide and involving an important economic and social burden. Up to 90% of CLBP is non-specific (not associated with specific injuries), with a chronicity expectation estimated at 10%. Currently, motivational and emotional central circuits are being investigated due to their role in CLBP persistency and chronification. Therefore, this narrative review aimed to summarize the evidence regarding the cortical brain changes described for proposing novel multidisciplinary approaches. Novel advances in neuroimaging techniques demonstrated structural (e.g., decrease in the grey matter located at the dorsolateral prefrontal cortex), functional (e.g., connectivity impairments in those areas involved in pain processing), and neurochemical changes (e.g., decrease in cerebral metabolites). In addition, significant changes were found in the primary somatosensory and motor cortex, contributing to the alteration of low back muscles activation and function. View Full-Text
Keywords: low back pain; cortical brain changes; neuroscience; chronic pain; neuroimaging low back pain; cortical brain changes; neuroscience; chronic pain; neuroimaging
MDPI and ACS Style

Medrano-Escalada, Y.; Plaza-Manzano, G.; Fernández-de-las-Peñas, C.; Valera-Calero, J.A. Structural, Functional and Neurochemical Cortical Brain Changes Associated with Chronic Low Back Pain. Tomography 2022, 8, 2153-2163. https://doi.org/10.3390/tomography8050180

AMA Style

Medrano-Escalada Y, Plaza-Manzano G, Fernández-de-las-Peñas C, Valera-Calero JA. Structural, Functional and Neurochemical Cortical Brain Changes Associated with Chronic Low Back Pain. Tomography. 2022; 8(5):2153-2163. https://doi.org/10.3390/tomography8050180

Chicago/Turabian Style

Medrano-Escalada, Yara, Gustavo Plaza-Manzano, César Fernández-de-las-Peñas, and Juan Antonio Valera-Calero. 2022. "Structural, Functional and Neurochemical Cortical Brain Changes Associated with Chronic Low Back Pain" Tomography 8, no. 5: 2153-2163. https://doi.org/10.3390/tomography8050180

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