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Article

Dynamic Contrast-Enhanced MRI in the Abdomen of Mice with High Temporal and Spatial Resolution Using Stack-of-Stars Sampling and KWIC Reconstruction

Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
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Academic Editor: Dariya Malyarenko
Tomography 2022, 8(5), 2113-2128; https://doi.org/10.3390/tomography8050178
Received: 6 July 2022 / Revised: 17 August 2022 / Accepted: 19 August 2022 / Published: 24 August 2022
(This article belongs to the Special Issue Advances in Co-clinical Quantitative Imaging Research)
Application of quantitative dynamic contrast-enhanced (DCE) MRI in mouse models of abdominal cancer is challenging due to the effects of RF inhomogeneity, image corruption from rapid respiratory motion and the need for high spatial and temporal resolutions. Here we demonstrate a DCE protocol optimized for such applications. The method consists of three acquisitions: (1) actual flip-angle B1 mapping, (2) variable flip-angle T1 mapping and (3) acquisition of the DCE series using a motion-robust radial strategy with k-space weighted image contrast (KWIC) reconstruction. All three acquisitions employ spoiled radial imaging with stack-of-stars sampling (SoS) and golden-angle increments between the views. This scheme is shown to minimize artifacts due to respiratory motion while simultaneously facilitating view-sharing image reconstruction for the dynamic series. The method is demonstrated in a genetically engineered mouse model of pancreatic ductal adenocarcinoma and yielded mean perfusion parameters of Ktrans = 0.23 ± 0.14 min−1 and ve = 0.31 ± 0.17 (n = 22) over a wide range of tumor sizes. The SoS-sampled DCE method is shown to produce artifact-free images with good SNR leading to robust estimation of DCE parameters. View Full-Text
Keywords: dynamic contrast enhanced; perfusion; radial; stack of stars; respiratory motion dynamic contrast enhanced; perfusion; radial; stack of stars; respiratory motion
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MDPI and ACS Style

Pickup, S.; Romanello, M.; Gupta, M.; Song, H.K.; Zhou, R. Dynamic Contrast-Enhanced MRI in the Abdomen of Mice with High Temporal and Spatial Resolution Using Stack-of-Stars Sampling and KWIC Reconstruction. Tomography 2022, 8, 2113-2128. https://doi.org/10.3390/tomography8050178

AMA Style

Pickup S, Romanello M, Gupta M, Song HK, Zhou R. Dynamic Contrast-Enhanced MRI in the Abdomen of Mice with High Temporal and Spatial Resolution Using Stack-of-Stars Sampling and KWIC Reconstruction. Tomography. 2022; 8(5):2113-2128. https://doi.org/10.3390/tomography8050178

Chicago/Turabian Style

Pickup, Stephen, Miguel Romanello, Mamta Gupta, Hee Kwon Song, and Rong Zhou. 2022. "Dynamic Contrast-Enhanced MRI in the Abdomen of Mice with High Temporal and Spatial Resolution Using Stack-of-Stars Sampling and KWIC Reconstruction" Tomography 8, no. 5: 2113-2128. https://doi.org/10.3390/tomography8050178

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